Evidence map›Paper›PMID 25074698›Full record

Trial reportJournal of the American Heart Association2014

Remote ischemic preconditioning in children undergoing cardiac surgery with cardiopulmonary bypass: a single-center double-blinded randomized trial.

Brian W McCrindle, Nadia A Clarizia, Svetlana Khaikin, Helen M Holtby, Cedric Manlhiot, Steven M Schwartz, Christopher A Caldarone, John G Coles, Glen S Van Arsdell, Stephen W Scherer and 1 more

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 31 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 6 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00650507 phase3completednot on this map

Clinical and Genomic Responses to Open Heart Surgery: A Randomized Controlled Trial of the Effects of Remote Ischemic Preconditioning

TypeinterventionalSponsorThe Hospital for Sick ChildrenRan2008 to 2012Enrolled300ConditionsIschemia-reperfusion (IR) InjuryArmsRemote ischemic preconditioning (RIPC), SHAM
NCT03166813 nacompletednot on this mapstarted 2017, after this paper: background citation

Remote Ischaemic Preconditioning in Paediatric Cancer Patients Receiving Anthracycline Therapy

TypeinterventionalSponsorThe University of Hong KongRan2017 to 2022Enrolled68ConditionsCardiotoxicityArmsRemote Ischaemic Preconditioning, Control
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 6 syntheses or guidelines pooled it, 71 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Remote ischaemic conditioning in necrotising enterocolitis: a phase I feasibility and safety study.Archives of disease in childhood. Fetal and neonatal edition · 2023
    Trial
  10. Trial
  11. Trial
  12. Article
  13. Article
  14. Article
  15. Article
  16. Remote ischemic conditioning for acute respiratory distress syndrome in COVID-19.American journal of physiology. Lung cellular and molecular physiology · 2021
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Brian W McCrindleLabatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada (B.W.M.C., N.A.C., S.K., H.M.H., C.M., S.M.S., C.A.C., J.G.C., G.S.V.A., A.N.R.) Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada (B.W.M.C., A.N.R.).
Nadia A ClariziaLabatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada (B.W.M.C., N.A.C., S.K., H.M.H., C.M., S.M.S., C.A.C., J.G.C., G.S.V.A., A.N.R.).
Svetlana KhaikinLabatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada (B.W.M.C., N.A.C., S.K., H.M.H., C.M., S.M.S., C.A.C., J.G.C., G.S.V.A., A.N.R.).
Helen M HoltbyLabatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada (B.W.M.C., N.A.C., S.K., H.M.H., C.M., S.M.S., C.A.C., J.G.C., G.S.V.A., A.N.R.) Department of Anesthesiology, University of Toronto, Toronto, Ontario, Canada (H.M.H.).
Cedric ManlhiotLabatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada (B.W.M.C., N.A.C., S.K., H.M.H., C.M., S.M.S., C.A.C., J.G.C., G.S.V.A., A.N.R.).
Steven M SchwartzLabatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada (B.W.M.C., N.A.C., S.K., H.M.H., C.M., S.M.S., C.A.C., J.G.C., G.S.V.A., A.N.R.) Department of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada (S.M.S.).
Christopher A CaldaroneLabatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada (B.W.M.C., N.A.C., S.K., H.M.H., C.M., S.M.S., C.A.C., J.G.C., G.S.V.A., A.N.R.) Department of Surgery, University of Toronto, Toronto, Ontario, Canada (C.A.C., J.G.C., G.S.V.A.).
John G ColesLabatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada (B.W.M.C., N.A.C., S.K., H.M.H., C.M., S.M.S., C.A.C., J.G.C., G.S.V.A., A.N.R.) Department of Surgery, University of Toronto, Toronto, Ontario, Canada (C.A.C., J.G.C., G.S.V.A.).
Glen S Van ArsdellLabatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada (B.W.M.C., N.A.C., S.K., H.M.H., C.M., S.M.S., C.A.C., J.G.C., G.S.V.A., A.N.R.) Department of Surgery, University of Toronto, Toronto, Ontario, Canada (C.A.C., J.G.C., G.S.V.A.).
Stephen W SchererThe McLaughlin Centre, University of Toronto, Toronto, Ontario, Canada (S.W.S.) The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, Ontario, Canada (S.W.S.).
Andrew N RedingtonLabatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada (B.W.M.C., N.A.C., S.K., H.M.H., C.M., S.M.S., C.A.C., J.G.C., G.S.V.A., A.N.R.) Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada (B.W.M.C., A.N.R.).
Hospital for Sick Children · CAUniversity of Toronto · CA

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

backgroundRemote ischemic preconditioning (RIPC) harnesses an innate defensive mechanism that protects against inflammatory activation and ischemia-reperfusion injury, known sequelae of cardiac surgery with cardiopulmonary bypass. We sought to determine the impact of RIPC on clinical outcomes and physiological markers related to ischemia-reperfusion injury and inflammatory activation after cardiac surgery in children. METHODS AND

resultsOverall, 299 children (aged neonate to 17 years) were randomized to receive an RIPC stimulus (inflation of a blood pressure cuff on the left thigh to 15 mm Hg above systolic for four 5-minute intervals) versus a blinded sham stimulus during induction with a standardized anesthesia protocol. Primary outcome was duration of postoperative hospital stay, with serial clinical and laboratory measurements for the first 48 postoperative hours and clinical follow-up to discharge. There were no significant baseline differences between RIPC (n=148) and sham (n=151). There were no in-hospital deaths. No significant difference in length of postoperative hospital stay was noted (sham 5.4 versus RIPC 5.6 days; difference +0.2; adjusted P=0.91), with the 95% confidence interval (-0.7 to +0.9) excluding a prespecified minimal clinically significant differences of 1 or 1.5 days. There were few significant differences in other clinical outcomes or values at time points or trends in physiological markers. Benefit was not observed in specific subgroups when explored through interactions with categories of age, sex, surgery type, Aristotle score, or first versus second half of recruitment. Adverse events were similar (sham 5%, RIPC 6%; P=0.68).

conclusionsRIPC is not associated with important improvements in clinical outcomes and physiological markers after cardiac surgery in children. CLINICAL TRIAL REGISTRATION URL: clinicaltrials.gov. Unique identifier: NCT00650507.

Indexed as

AdolescentCardiac Surgical ProceduresCardiopulmonary BypassChildChild, PreschoolDouble-Blind MethodFemaleHumansInfantInfant, NewbornInflammationIschemic PreconditioningLength of StayLower ExtremityMaleMyocardial Reperfusion Injurycongenitalheart defectspediatricsremote ischemic preconditioningsurgery

Identifiers

PMID25074698
PMCPMC4310383
OpenAlexW2129561999

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.