ReviewJournal of neuroendocrinology2014
Emotion and mood adaptations in the peripartum female:complementary contributions of GABA and oxytocin.
Review in Journal of neuroendocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 78 citations in OpenAlex.
- Maternal brain alterations based on neurotransmitter and hormone receptor distributions over six months postpartum.Translational psychiatry · 2026Article
- The relationship between self-efficacy and prenatal depression in Chinese pregnant women: a parallel latent growth curve model.BMC psychiatry · 2025Article
- Postpartum depression in rats causes poor maternal care and neurochemical alterations on dams and long-lasting impairment in sociability on the offspring.Behavioural brain research · 2023Article
- Mitochondrial might: powering the peripartum for risk and resilience.Frontiers in behavioral neuroscience · 2023Review
- MIESRA mHealth: Marital satisfaction during pregnancy.PloS one · 2023Article
- Receptor for advanced glycation end-products and child neglect in mice: A possible link to postpartum depression.Comprehensive psychoneuroendocrinology · 2022Review
- Lateral habenula neurocircuits mediate the maternal disruptive effect of maternal stress: A hypothesis.Zoological research · 2022Review
- GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan.Frontiers in behavioral neuroscience · 2022Review
- The combination of fluoxetine and environmental enrichment reduces postpartum stress-related behaviors through the oxytocinergic system and HPA axis in mice.Scientific reports · 2021Article
- GABA in the medial prefrontal cortex regulates anxiety-like behavior during the postpartum period.Behavioural brain research · 2021Article
- How stress can influence brain adaptations to motherhood.Frontiers in neuroendocrinology · 2021Review
- Neurobiology of peripartum mental illness.Handbook of clinical neurology · 2021Review
- Article
- Identification of the significant pathways of Banxia Houpu decoction in the treatment of depression based on network pharmacology.PloS one · 2020Article
- Allopregnanolone-based treatments for postpartum depression: Why/how do they work?Neurobiology of stress · 2019Article
- A novel role of oxytocin: Oxytocin-induced well-being in humans.Biophysics and physicobiology · 2019Article
- Neuroactive Steroids and GABAergic Involvement in the Neuroendocrine Dysfunction Associated With Major Depressive Disorder and Postpartum Depression.Frontiers in cellular neuroscience · 2019Review
- Thalamic integration of social stimuli regulating parental behavior and the oxytocin system.Frontiers in neuroendocrinology · 2018Review
- Maternal programming: Application of a developmental psychopathology perspective.Development and psychopathology · 2018Review
- Serotonin-specific lesions of the dorsal raphe disrupt maternal aggression and caregiving in postpartum rats.Behavioural brain research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 3 countries.
Funding
Abstract
Peripartum hormones and sensory cues from young modify the maternal brain in ways that can render females either at risk for, or resilient to, elevated anxiety and depression. The neurochemical systems underlying these aspects of maternal emotional and mood states include the inhibitory neurotransmitter GABA and the neuropeptide oxytocin (OXT). Data from laboratory rodents indicate that increased activity at the GABA(A) receptor contributes to the postpartum suppression of anxiety-related behaviour that is mediated by physical contact with offspring, whereas dysregulation in GABAergic signalling results in deficits in maternal care, as well as anxiety- and depression-like behaviours during the postpartum period. Similarly, activation of the brain OXT system accompanied by increased OXT release within numerous brain sites in response to reproductive stimuli also reduces postpartum anxiety- and depression-like behaviours. Studies of peripartum women are consistent with these findings in rodents. Given the similar consequences of elevated central GABA and OXT activity on maternal anxiety and depression, balanced and partly reciprocal interactions between these two systems may be essential for their effects on maternal emotional and mood states, in addition to other aspects of postpartum behaviour and physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.