ArticleJournal of molecular histology2014
Expression of Nfic during root formation in first mandibular molar of rat.
Article in Journal of molecular histology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Integrated Single-cell Analysis Uncovers Regulatory Logic of Cranial Ectoderm Development.bioRxiv : the preprint server for biology · 2025Article
- NFIC promotes the vitality and osteogenic differentiation of rat dental follicle cells.Journal of molecular histology · 2019Article
- Changes of mitochondrial respiratory function during odontogenic differentiation of rat dental papilla cells.Journal of molecular histology · 2018Article
- The role of nuclear factor I-C in tooth and bone development.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2017Review
- Hyaluronan and hyaluronan synthases expression and localization in embryonic mouse molars.Journal of molecular histology · 2016Article
- Facioscapulohumeral muscular dystrophy (FSHD) region gene 1 (FRG1) expression and possible function in mouse tooth germ development.Journal of molecular histology · 2016Article
- Spatiotemporal expression of caveolin-1 and EMMPRIN during mouse tooth development.Journal of molecular histology · 2016Article
- NFI-C2 temporal-spatial expression and cellular localization pattern during tooth formation.Development, growth & differentiation · 2015Article
- Functional role of EMMPRIN in the formation and mineralisation of dental matrix in mouse molars.Journal of molecular histology · 2015Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transcription factor Nfic is a key regulator during tooth development. Nfic deficient mice exhibit short and abnormal molar roots and severely deformed incisors. Dental epithelial cells, known as Hertwig's epithelial root sheath (HERS), participate in root formation. However, whether Nfic is involved in HERS-mesenchyme interaction remains unclear. In this study, the detail temporal and spatial expression pattern of Nfic during rat molar development was examined using immunohistochemistry and in situ hybridization. Nfic was detected in ameloblasts, dental follicle cells (DFCs) and dental papilla cells (DPCs), especially the DPCs close to dentin, from postnatal day 5 to day 16. Nfic expression in DPCs, DFCs and HERS cells was also examined by western blot and RT-PCR. Nfic was detected in DPCs and DFCs, but not in HERS cells. Co-culture experiment further indicated that Nfic mRNA expression in DPCs was elevated by the presence of HERS cells. Our results revealed that Nfic could be a marker gene for root odontoblasts differentiation initiation and its expression might be regulated through epithelial-mesenchymal interaction.
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