SynthesisJournal of dental research2014
Newly identified pathogens associated with periodontitis: a systematic review.
Synthesis in Journal of dental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 180 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Periodontal Therapy on Patients With Diabetes: A Pilot Study
Evaluating Safety and Efficacy of Oral-Spray Bacillus Spore Probiotics (LiveSpo Smile CARE) in Preventing and Supporting the Treatment of Periodontal Diseases in Elderly in Hanoi
Who cites it
180 citing papers in PubMed, 4 syntheses or guidelines pooled it, 360 citations in OpenAlex.
- Microbial signatures in human periodontal disease: a metatranscriptome meta-analysis.Frontiers in microbiology · 2024Pooled it
- Assessment of the role of Trichomonas tenax in the etiopathogenesis of human periodontitis: A systematic review.PloS one · 2019Pooled it
- Differences in the subgingival microbial population of chronic periodontitis in subjects with and without type 2 diabetes mellitus-a systematic review.Clinical oral investigations · 2018Pooled it
- The microbial changes in subgingival plaques of orthodontic patients: a systematic review and meta-analysis of clinical trials.BMC oral health · 2017Pooled it
- Assessing the Impact ofNutrients · 2026Trial
- Evolution in the Peri-Implant Oral Microbiome and Their Relationship to Long-Term Marginal Bone Loss: A Randomized Clinical Study.Clinical oral implants research · 2025Trial
- Personalized antibiotic selection in periodontal treatment improves clinical and microbiological outputs.Frontiers in cellular and infection microbiology · 2023Trial
- Periodontal Treatment and Usual Care for Nonalcoholic Fatty Liver Disease: A Multicenter, Randomized Controlled Trial.Clinical and translational gastroenterology · 2022Trial
- Mechanical biofilm disruption causes microbial and immunological shifts in periodontitis patients.Scientific reports · 2021Trial
- Clinical utility of subgingival plaque-specific bacteria in salivary microbiota for detecting periodontitis.PloS one · 2021Trial
- Trial
- Moderating Effects of Oral Bacteria and Tooth Loss on Cognitive Performance.JDR clinical and translational research · 2026Article
- Therapeutic Efficacy of Floating Electrode-Dielectric Barrier Discharge Plasma in Experimental Periodontitis: A Pilot Study.Bioengineering (Basel, Switzerland) · 2026Article
- The subgingival microbiome in periodontitis: from ecological dysbiosis and metabolic reprogramming to precision interventions.Frontiers in microbiology · 2026Review
- Oral microbiome profiles by periodontitis stage in a Korean population.Frontiers in cellular and infection microbiology · 2026Article
- Murine Models of Experimental Periodontal Disease.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Microbiological and Metabolomic Analysis of Biomarkers for Grades A and B in Stage II Periodontitis.Inflammation · 2025Article
- Impact of Prolonged Fasting on the Oral Microbiome in Patients With Metabolic Syndrome: An Exploratory Secondary Analysis.Journal of clinical periodontology · 2025Article
- Enhancing Professional Periodontal Therapy with a Novel PMA-Zeolite Application: A Clinical Study on Periodontal Outcomes and Microbiological Changes.Journal of functional biomaterials · 2025Article
- Periodontitis History Shapes the Early Peri-Implant Microbiome Formation: A Metagenomic Analysis.Journal of clinical periodontology · 2025Article
120 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is substantial evidence supporting the role of certain oral bacteria species in the onset and progression of periodontitis. Nevertheless, results of independent-culture diagnostic methods introduced about a decade ago have pointed to the existence of new periodontal pathogens. However, the data of these studies have not been evaluated together, which may generate some misunderstanding on the actual role of these microorganisms in the etiology of periodontitis. The aim of this systematic review was to determine the current weight of evidence for newly identified periodontal pathogens based on the results of "association" studies. This review was conducted and reported in accordance with the PRISMA statement. The MEDLINE, EMBASE, and Cochrane databases were searched up to September 2013 for studies (1) comparing microbial data of subgingival plaque samples collected from subjects with periodontitis and periodontal health and (2) evaluating at least 1 microorganism other than the already-known periodontal pathogens. From 1,450 papers identified, 41 studies were eligible. The data were extracted and registered in predefined piloted forms. The results suggested that there is moderate evidence in the literature to support the association of 17 species or phylotypes from the phyla Bacteroidetes, Candidatus Saccharibacteria, Firmicutes, Proteobacteria, Spirochaetes, and Synergistetes. The phylum Candidatus Saccharibacteria and the Archaea domain also seem to have an association with disease. These data point out the importance of previously unidentified species in the etiology of periodontitis and might guide future investigations on the actual role of these suspected new pathogens in the onset and progression of this infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.