ArticleEuropean journal of clinical nutrition2015
Correlation of serum adiponectin and adiponectin gene polymorphism with metabolic syndrome in Chinese adolescents.
Article in European journal of clinical nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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20 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Pooled it
- Role of Adipokines in the Development of Metabolic Syndrome in Patients With Polycystic Ovary Syndrome.Cureus · 2025Article
- Correlation of serum adiponectin with thyroid profile among metabolic syndrome patients with and without hypothyroidism.Bioinformation · 2025Article
- Insulin resistance-related circulating predictive markers in the metabolic syndrome: a systematic review in the Iranian population.Journal of diabetes and metabolic disorders · 2024Review
- ADIPOQ gene (T45G and G276T) single nucleotide polymorphisms and their association with gestational diabetes mellitus in a Filipino population.BMC endocrine disorders · 2023Article
- Population serum proteomics uncovers a prognostic protein classifier for metabolic syndrome.Cell reports. Medicine · 2023Article
- Dissecting the Molecular Role ofBiomedicines · 2023Article
- Effect of Genetic Variations in theDiabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Association of AdipoQ gene variation (rs1501299) and oxidative stress with cardiovascular disease in North West Indian population of Punjabi women.Journal of medical biochemistry · 2021Article
- Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents.Diabetology & metabolic syndrome · 2019Article
- Polymorphism Of TheDiabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- The Relationship of adiponectin level andDermato-endocrinology · 2018Article
- Article
- Hypoadiponectemia is associated with metabolic syndrome in patients with type 2 diabetes.International journal of clinical and experimental pathology · 2017Article
- High Molecular Weight Adiponectin Levels are Neither Influenced by Adiponectin Polymorphisms Nor Associated with Insulin Resistance in Mixed-ancestry Hyperglycemic Subjects from South Africa.Journal of medical biochemistry · 2016Article
- Serum adiponectin, its gene polymorphism and metabolic syndrome in adolescents.European journal of clinical nutrition · 2016Article
- Association between adiponectin polymorphisms and the risk of colorectal cancer.Genetic testing and molecular biomarkers · 2015Article
- Association of adiponectin gene polymorphism with adiponectin levels and risk for insulin resistance syndrome.International journal of preventive medicine · 2015Article
- Adiponectin is not associated with blood pressure in normotensives and untreated hypertensives with normal kidney function.Medicine · 2014Observational
- Genetic Determination of Serum Levels of Diabetes-Associated Adipokines.The review of diabetic studies : RDSReview
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6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesTo investigate the association of adiponectin and its gene polymorphisms with metabolic syndrome (MetS) and cardiovascular disease (CVD) risk factors in Chinese adolescents. SUBJECTS/
methodsThis cross-sectional study enrolled 919 healthy middle school students (aged 11-16 years; 46.7% females). All participants underwent anthropometric and biochemical examinations, and MetS was diagnosed using 2007 International Diabetes Federation criteria. The presence of adiponectin and its genotypes of single nucleotide polymorphisms (SNPs) rs266729 (-11377C/G), rs2241766 (+45T/G) and rs1501299 (+276G/T) was detected.
results(1) Serum adiponectin levels were negatively correlated with numerous CVD risk factors (all P<0.05), and following adjustments for confounding factors, a lower adiponectin level was an independent risk factor for MetS (odds ratio=5.59; 95% confidence interval: 1.90, 16.41). Central obesity and low levels of high-density lipoprotein cholesterol were positively associated with MetS and reduced serum adiponectin levels. (2) The genotype and frequencies of SNP-11377 and SNP+276 in a MetS group and non-MetS group were not significantly different. Subjects with genotype SNP+45 GG were at higher risk for MetS compared with subjects with genotypes SNP+45 TT (P=0.033) or TT+TG (P=0.021). Subjects with genotype SNP+276 TT or TT+TG had higher levels of serum adiponectin compared with subjects with SNP+276 GG (P=0.012 and 0.014, respectively).
conclusionsAdiponectin may be used as a predictive biomarker of MetS, and shows a significant association with CVD risk factors in Chinese adolescents. Adiponectin gene polymorphisms are associated with serum adiponectin concentrations and the presence of MetS.
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