ArticleJournal of the Association for Research in Otolaryngology : JARO2014
How to bury the dead: elimination of apoptotic hair cells from the hearing organ of the mouse.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 64 citations in OpenAlex.
- Supporting cell involvement in cochlear damage and repair: Novel insights from a quantitative analysis of cyclodextrin-induced ototoxicity in mice.Hearing research · 2025Article
- Expression of S100β during mouse cochlear development.European journal of histochemistry : EJH · 2025Article
- Organ of Corti macrophages: a distinct group of cochlear macrophages with potential roles in supporting cell degeneration and survival.Frontiers in immunology · 2025Article
- Roles of supporting cells in the maintenance and regeneration of the damaged inner ear: A literature review.Journal of otology · 2024Review
- Proteins required for stereocilia elongation during mammalian hair cell development ensure precise and steady heights during adult life.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Modulating the unfolded protein response with ISRIB mitigates cisplatin ototoxicity.Scientific reports · 2024Article
- Combinatorial Atoh1, Gfi1, Pou4f3, and Six1 gene transfer induces hair cell regeneration in the flat epithelium of mature guinea pigs.Hearing research · 2024Article
- Absence of oncomodulin increases susceptibility to noise-induced outer hair cell death and alters mitochondrial morphology.Frontiers in neurology · 2024Article
- Age-related changes in P2Y receptor signalling in mouse cochlear supporting cells.The Journal of physiology · 2023Article
- Regeneration of Hair Cells from Endogenous Otic Progenitors in the Adult Mammalian Cochlea: Understanding Its Origins and Future Directions.International journal of molecular sciences · 2023Review
- In vivo investigation of mitochondria in lateral line afferent neurons and hair cells.Hearing research · 2023Review
- Precise alternating cellular pattern in the inner ear by coordinated hopping intercalations and delaminations.Science advances · 2023Article
- Diversity of developing peripheral glia revealed by single-cell RNA sequencing.Developmental cell · 2021Article
- Cytoarchitecture and innervation of the mouse cochlear amplifier revealed by large-scale volume electron microscopy.The Journal of comparative neurology · 2021Article
- Phosphorylation of MYL12 by Myosin Light Chain Kinase Regulates Cellular Shape Changes in Cochlear Hair Cells.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Scar Formation and Debris Elimination during Hair Cell Degeneration in the Adult DTR Mouse.Neuroscience · 2021Article
- Actin Crosslinking Family Protein 7 Deficiency Does Not Impair Hearing in Young Mice.Frontiers in cell and developmental biology · 2021Article
- Some Ototoxic Drugs Destroy Cochlear Support Cells Before Damaging Sensory Hair Cells.Neurotoxicity research · 2020Article
- Macrophages Respond Rapidly to Ototoxic Injury of Lateral Line Hair Cells but Are Not Required for Hair Cell Regeneration.Frontiers in cellular neuroscience · 2020Article
- Cell-Specific Transcriptional Responses to Heat Shock in the Mouse Utricle Epithelium.Frontiers in cellular neuroscience · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hair cell death is a major cause of hearing impairment. Preservation of surface barrier upon hair cell loss is critical to prevent leakage of potassium-rich endolymph into the organ of Corti and to prevent expansion of cellular damage. Understanding of wound healing in this cytoarchitecturally complex organ requires ultrastructural 3D visualization. Powered by the serial block-face scanning electron microscopy, we penetrate into the cell biological mechanisms in the acute response of outer hair cells and glial-like Deiters' cells to ototoxic trauma in vivo. We show that Deiters' cells function as phagocytes. Upon trauma, their phalangeal processes swell and the resulting close cellular contacts allow engulfment of apoptotic cell debris. Apical domains of dying hair cells are eliminated from the inner ear sensory epithelia, an event thought to depend on supporting cells' actomyosin contractile activity. We show that in the case of apoptotic outer hair cells of the organ of Corti, elimination of their apices is preceded by strong cell body shrinkage, emphasizing the role of the dying cell itself in the cleavage. Our data reveal that the resealing of epithelial surface by junctional extensions of Deiters' cells is dynamically reinforced by newly polymerized F-actin belts. By analyzing Cdc42-inactivated Deiters' cells with defects in actin dynamics and surface closure, we show that compromised barrier integrity shifts hair cell death from apoptosis to necrosis and leads to expanded hair cell and nerve fiber damage. Our results have implications concerning therapeutic protective and regenerative interventions, because both interventions should maintain barrier integrity.
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