ArticleeLife2014
Enhancement of encoding and retrieval functions through theta phase-specific manipulation of hippocampus.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 1 of them a synthesis that pooled it.
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Who cites it
156 citing papers in PubMed, 1 synthesis or guideline pooled it, 283 citations in OpenAlex.
- A Systematic Review of Closed-Loop Feedback Techniques in Sleep Studies-Related Issues and Future Directions.Sensors (Basel, Switzerland) · 2020Pooled it
- Integrating neural decoding, memristive materials, and adaptive control frameworks for next-generation hippocampal memory prosthetics.iScience · 2026Review
- Acetylcholine: a candidate substrate for hippocampal predictive learning?Nature reviews. Neuroscience · 2026Review
- Development of an automated REM sleep deprivation device for mice in neuroscience research.HardwareX · 2026Article
- Episodic memory encoding fluctuates at a theta rhythm of 3-10 Hz.Nature human behaviour · 2026Article
- Entorhinal cortex represents task-relevant remote locations independently of CA1.Nature neuroscience · 2026Article
- Bifurcation of spiking oscillations from a center in resonate-and-fire neurons.Biological cybernetics · 2026Article
- Optimizing real-time phase detection in diverse rhythmic biological signals for phase-specific neurostimulation.Journal of neural engineering · 2025Article
- A real-time all-optical interface for dynamic perturbation of neural activity during behavior.Cell reports methods · 2025Article
- Nonspecific ensemble reactivation in mouse dentate gyrus disrupts spatial working memory.iScience · 2025Article
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- Disruption of theta-timescale spiking impairs learning but spares hippocampal replay.bioRxiv : the preprint server for biology · 2025Article
- Interneuron theta phase locking controls seizure susceptibility.bioRxiv : the preprint server for biology · 2025Article
- Hippocampal-Prefrontal Communication Subspaces Align with Behavioral and Network Patterns in a Spatial Memory Task.eNeuro · 2025Article
- Selective inhibition in CA3: A mechanism for stable pattern completion through heterosynaptic plasticity.PLoS computational biology · 2025Article
- Human single-neuron activity is modulated by intracranial theta burst stimulation of the basolateral amygdala.bioRxiv : the preprint server for biology · 2025Article
- Closed-loop control of theta oscillations enhances human hippocampal network connectivity.Nature communications · 2025Article
- Medial septal theta stimulation enhances spatial working memory performance in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2025Article
- Timing is everything: The effect of early-life seizures on developing neuronal circuits subserving spatial memory.Epilepsia open · 2025Review
96 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Assessing the behavioral relevance of the hippocampal theta rhythm has proven difficult, due to a shortage of experiments that selectively manipulate phase-specific information processing. Using closed-loop stimulation, we triggered inhibition of dorsal CA1 at specific phases of the endogenous theta rhythm in freely behaving mice. This intervention enhanced performance on a spatial navigation task that requires the encoding and retrieval of information related to reward location on every trial. In agreement with prior models of hippocampal function, the behavioral effects depended on both the phase of theta and the task segment at which we stimulated. Stimulation in the encoding segment enhanced performance when inhibition was triggered by the peak of theta. Conversely, stimulation in the retrieval segment enhanced performance when inhibition was triggered by the trough of theta. These results suggest that processes related to the encoding and retrieval of task-relevant information are preferentially active at distinct phases of theta.DOI: http://dx.doi.org/10.7554/eLife.03061.001.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.