ArticlemBio2014
Antivirulence activity of the human gut metabolome.
Article in mBio, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Article
- Article
- The Therapeutic Potential of Gut-Microbiota-Derived Metabolite 4-Phenylbutyric Acid inInternational journal of molecular sciences · 2025Article
- Potential relationship between gut microbiota and animal diarrhea: a systematic review.Frontiers in microbiology · 2025Review
- Microbes as medicine.Annals of the New York Academy of Sciences · 2024Review
- ProbioticAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Microbiota-Liver Diseases Interactions.International journal of molecular sciences · 2023Review
- Threonine Facilitates Cd Excretion by Increasing the Abundance of GutMolecules (Basel, Switzerland) · 2022Article
- Article
- Antibiofilm activity of Cutibacterium acnes cell-free conditioned media against Staphylococcus spp.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Gut Microbiota and Diarrhea: An Updated Review.Frontiers in cellular and infection microbiology · 2021Review
- Elucidating potential molecular signatures through host-microbe interactions for reactive arthritis and inflammatory bowel disease using combinatorial approach.Scientific reports · 2020Article
- Small Molecules Produced by Commensal Staphylococcus epidermidis Disrupt Formation of Biofilms by Staphylococcus aureus.Applied and environmental microbiology · 2020Article
- Defensive Symbioses in Social Insects Can Inform Human Health and Agriculture.Frontiers in microbiology · 2020Article
- Dysbiosis: from fiction to function.American journal of physiology. Gastrointestinal and liver physiology · 2019Review
- Evolutionary and ecological consequences of gut microbial communities.Annual review of ecology, evolution, and systematics · 2019Article
- The Gut Microbiome and Metabolome of Two Riparian Communities in the Amazon.Frontiers in microbiology · 2019Article
- Dynamic linear models guide design and analysis of microbiota studies within artificial human guts.Microbiome · 2018Article
- Article
- Gut microbes as future therapeutics in treating inflammatory and infectious diseases: Lessons from recent findings.The Journal of nutritional biochemistry · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
The mammalian gut contains a complex assembly of commensal microbes termed microbiota. Although much has been learned about the role of these microbes in health, the mechanisms underlying these functions are ill defined. We have recently shown that the mammalian gut contains thousands of small molecules, most of which are currently unidentified. Therefore, we hypothesized that these molecules function as chemical cues used by hosts and microbes during their interactions in health and disease. Thus, a search was initiated to identify molecules produced by the microbiota that are sensed by pathogens. We found that a secreted molecule produced by clostridia acts as a strong repressor of Salmonella virulence, obliterating expression of the Salmonella pathogenicity island 1 as well as host cell invasion. It has been known for decades that the microbiota protects its hosts from invading pathogens, and these data suggest that chemical sensing may be involved in this phenomenon. Further investigations should reveal the exact biological role of this molecule as well as its therapeutic potential. Importance: Microbes can communicate through the production and sensing of small molecules. Within the complex ecosystem formed by commensal microbes living in and on the human body, it is likely that these molecular messages are used extensively during the interactions between different microbial species as well as with host cells. Deciphering such a molecular dialect will be fundamental to our understanding of host-microbe interactions in health and disease and may prove useful for the design of new therapeutic strategies that target these mechanisms of communication.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.