ArticleJournal of the neurological sciences2014
The effects of cystatin C and alkaline phosphatase changes on cognitive function 12-months after bariatric surgery.
Article in Journal of the neurological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Changes in Cognitive Function Following Bariatric Surgery: An Updated Systematic Review.Obesity surgery · 2024Pooled it
- Bariatric Surgery Improves Cognition Function in the Patients with Obesity: A Meta-Analysis.Obesity surgery · 2024Pooled it
- The Executive Functions in Overweight and Obesity: A Systematic Review of Neuropsychological Cross-Sectional and Longitudinal Studies.Frontiers in psychology · 2019Pooled it
- Changes in Cognitive Function Following Bariatric Surgery: a Systematic Review.Obesity surgery · 2016Pooled it
- NHANES 2011-2014: Association Between Conicity Index and Cognitive Performance in Older Adults.Alpha psychiatry · 2025Article
- Response to Dr. Buchwald.Obesity surgery · 2024Article
- Impact of Bariatric Surgery on Circulating Metabolites and Cognitive Performance.Obesity surgery · 2024Article
- Cognitive functioning in adolescents with severe obesity undergoing bariatric surgery or intensive non-surgical treatment in Sweden (AMOS2): a multicentre, open-label, randomised controlled trial.EClinicalMedicine · 2024Article
- Cystatins: unravelling the biological implications for neuroprotection.Archives of medical science : AMS · 2024Article
- The Effect of Surgical Weight Loss on Cognition in Individuals with Class II/III Obesity.The journal of nutrition, health & aging · 2023Article
- Article
- Cystatin C relates to metabolism in healthy, pubertal adolescents.Pediatric nephrology (Berlin, Germany) · 2022Article
- Higher Cystatin C Levels Are Associated With Neurocognitive Impairment in Older HIV+ Adults.Journal of acquired immune deficiency syndromes (1999) · 2017Article
Corrections and comments
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Authors and funding
8 authors.
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Abstract
backgroundThe mechanisms for improved cognitive function post-bariatric surgery are not well understood. Markers of kidney and liver function (i.e., cystatin C and alkaline phosphatase (ALP)) are elevated in obese individuals and associated with poor neurocognitive outcomes in other samples. Bariatric surgery can improve cystatin C and ALP levels, but no study has examined whether such changes correspond to post-operative cognitive benefits.
methods78 bariatric surgery patients completed a computerized cognitive test battery prior to and 12-months after surgery. All participants underwent an eight-hour fasting blood draw to quantify cystatin C and ALP concentrations.
resultsCognitive function improved after surgery. Cystatin C levels decreased at the 12-month follow-up; however, no changes were found in ALP concentrations. At baseline, higher cystatin C levels predicted worse attention/executive function, but no such effects emerged for ALP. Regression analyses controlling for possible medical and demographic confounds and baseline factors revealed that decreased ALP levels following surgery predicted better attention/executive function and memory abilities. Post-surgery changes in cystatin C did not correspond to cognitive improvements.
conclusionsDecreased ALP levels predicted better cognition following bariatric surgery, suggesting improved liver function as a possible mechanism of post-operative cognitive benefits. Future studies with neuroimaging and longer follow-up periods are needed to determine whether bariatric surgery can decrease risk for adverse brain changes and dementia in severely obese persons via improved metabolic function.
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