ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2014
TGF-β signaling regulates fibrotic expression and activity in carpal tunnel syndrome.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Altered blood-based biomarkers in carpal tunnel syndrome. A systematic review and meta-analysis.Musculoskeletal science & practice · 2026Pooled it
- A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome.Nature communications · 2022Pooled it
- Collagen gel contraction as a measure of fibroblast function in carpal tunnel syndrome.Journal of biomedical materials research. Part A · 2015Trial
- Inflammation in Carpal Tunnel Syndrome: A Systematic Review and Meta-Analysis of the Immune Profile.Journal of clinical medicine · 2026Review
- Influence of high-fat diet and sex on connective tissue in carpal tunnel syndrome.Scientific reports · 2026Article
- Temporal- and concentration-dependent effects of transforming growth factor-beta 1 (TGF-β1) in primary human knee fibroblasts.Bone & joint research · 2025Article
- Biomimetic hydrogel scaffolds for stimulating fibrotic responses: development of an in-vitro assay for implant material testing.Frontiers in bioengineering and biotechnology · 2025Article
- Transforming growth factor-β receptors: versatile mechanisms of ligand activation.Acta pharmacologica Sinica · 2024Review
- Carpal Tunnel Syndrome and Trigger Finger May Be an Early Symptom of Preclinic Type 2 Diabetes.Plastic and reconstructive surgery. Global open · 2024Article
- Higher densities of T-lymphocytes in the subsynovial connective tissue of people with carpal tunnel syndrome.PloS one · 2024Article
- Serum Transforming Growth Factor β1 and Its Genetic Variants Are Associated with Increased Macrophage Inflammatory Protein 1β and Susceptibility to Idiopathic Carpal Tunnel Syndrome.Journal of personalized medicine · 2023Article
- Serum Levels of Inflammatory and Fibrotic Cytokines in Patients with Carpal Tunnel Syndrome and Hip Osteoarthritis.Biomedicines · 2022Article
- Fibrosis-Associated Signaling Molecules Are Differentially Expressed in Palmar Connective Tissues of Patients with Carpal Tunnel Syndrome and Dupuytren's Disease.Biomedicines · 2022Article
- Association between hormone replacement therapy and carpal tunnel syndrome: a nationwide population-based study.BMJ open · 2022Article
- Effect of a monocyte chemoattractant protein-1 synthesis inhibitor on fibroblasts from patients with carpal tunnel syndrome.Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2021Article
- Blocking CTGF/CCN2 reverses neural fibrosis and sensorimotor declines in a rat model of overuse-induced median mononeuropathy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- ERK1/2 drives IL-1β-induced expression of TGF-β1 and BMP-2 in torn tendons.Scientific reports · 2019Article
- Study of the mechanism underlying hsa-miR338-3p downregulation to promote fibrosis of the synovial tissue in osteoarthritis patients.Molecular biology reports · 2019Article
- Triamcinolone Acetonide affects TGF-β signaling regulation of fibrosis in idiopathic carpal tunnel syndrome.BMC musculoskeletal disorders · 2018Article
- Blocking fibrotic signaling in fibroblasts from patients with carpal tunnel syndrome.Journal of cellular physiology · 2018Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Fibrosis of the subsynovial connective tissue (SSCT) is a predominant feature of carpal tunnel syndrome (CTS). While the nature of CTS has been extensively studied, little is known about the etiology of this disease. We investigated SSCT tissue from patients with CTS and control subjects using fibrosis arrays and cell culture analysis. Twofold changes in fibrotic gene expression were found in multiple genes from patient SSCT using fibrosis arrays. This data was confirmed via qRT-PCR on a subset of genes; collagen I (Col1), collagen III (Col3), connective tissue growth factor (CTGF), transforming growth factor β (TGF-β), and SMAD3 (P < 0.05) which significantly corroborate the fold changes found in the fibrosis arrays. To further explore the nature of SSCT fibrosis, cells were isolated from patient and control tissue. Col1, Col3, TGF-β, and SMAD3 were highly expressed in patient SSCT fibroblasts as compared to control (P < 0.05). Further, fibrotic genes expression was decreased by inhibiting TGF-β receptor I (TβRI) activity (P < 0.05). TGF-β second messenger SMAD activity was significantly activated in SSCT fibroblasts from patients and this activation was abrogated by inhibiting TβRI signaling (P < 0.05). These findings suggest that blocking TGF-β signaling may be an important therapeutic approach to treating the underlying fibrosis of SSCT in CTS patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.