ReviewAmerican journal of obstetrics and gynecology2014
Prediction of preterm birth in twin gestations using biophysical and biochemical tests.
Review in American journal of obstetrics and gynecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 7 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Diagnosis or prognosis? An umbrella review of mid-trimester cervical length and spontaneous preterm birth.BJOG : an international journal of obstetrics and gynaecology · 2023Pooled it
- Vaginal progesterone is as effective as cervical cerclage to prevent preterm birth in women with a singleton gestation, previous spontaneous preterm birth, and a short cervix: updated indirect comparison meta-analysis.American journal of obstetrics and gynecology · 2018Pooled it
- Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix: a meta-analysis of individual patient data.American journal of obstetrics and gynecology · 2018Pooled it
- Vaginal progesterone decreases preterm birth and neonatal morbidity and mortality in women with a twin gestation and a short cervix: an updated meta-analysis of individual patient data.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2017Pooled it
- Vaginal progesterone decreases preterm birth ≤ 34 weeks of gestation in women with a singleton pregnancy and a short cervix: an updated meta-analysis including data from the OPPTIMUM study.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2016Pooled it
- Cervical phosphorylated insulin-like growth factor binding protein-1 test for the prediction of preterm birth: a systematic review and metaanalysis.American journal of obstetrics and gynecology · 2016Pooled it
- Prophylactic oral betamimetics for reducing preterm birth in women with a twin pregnancy.The Cochrane database of systematic reviews · 2015Pooled it
- Effects of emergency/nonemergency cervical cerclage on the vaginal microbiome of pregnant women with cervical incompetence.Frontiers in cellular and infection microbiology · 2023Trial
- Trial
- Nomogram model for predicting spontaneous preterm birth in twin pregnancies: a case-control study.BMC pregnancy and childbirth · 2026Article
- Longitudinal Ultrasound Evaluation of Cervical Length for Predicting Spontaneous Preterm Delivery Before 34 Weeks in Twin Gestations: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Prediction of preterm birth from cervical length measurements in twin pregnancies using machine learning.Scientific reports · 2025Article
- Clinical guidance VVOG: Antenatal care for twin pregnancies.European journal of obstetrics & gynecology and reproductive biology: X · 2025Article
- ISUOG Practice Guidelines (updated): role of ultrasound in twin pregnancy.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Article
- The clinic application of mNGS and ENA-78 assays to identify intra-amniotic infection/inflammation.Frontiers in cellular and infection microbiology · 2025Article
- Counselling in Fetal Medicine: Uncomplicated Twin Pregnancies.Journal of clinical medicine · 2024Review
- Low PAPPA and Its Association with Adverse Pregnancy Outcomes in Twin Pregnancies: A Systematic Review of the Literature and Meta-Analysis.Journal of clinical medicine · 2024Review
- Is the Early Screening of Lower Genital Tract Infections Useful in Preventing Adverse Obstetrical Outcomes in Twin Pregnancy?Journal of clinical medicine · 2024Article
- Development and validation of a prediction model on spontaneous preterm birth in twin pregnancy: a retrospective cohort study.Reproductive health · 2023Article
- Preterm labor with intact membranes: a simple noninvasive method to identify patients at risk for intra-amniotic infection and/or inflammation.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The objective of this study was to determine the performance of biophysical and biochemical tests for the prediction of preterm birth in both asymptomatic and symptomatic women with twin gestations. We identified a total of 19 tests proposed to predict preterm birth, mainly in asymptomatic women. In these women, a single measurement of cervical length with transvaginal ultrasound before 25 weeks of gestation appears to be a good test to predict preterm birth. Its clinical potential is enhanced by the evidence that vaginal progesterone administration in asymptomatic women with twin gestations and a short cervix reduces neonatal morbidity and mortality associated with spontaneous preterm delivery. Other tests proposed for the early identification of asymptomatic women at increased risk of preterm birth showed minimal to moderate predictive accuracy. None of the tests evaluated in this review meet the criteria to be considered clinically useful to predict preterm birth among patients with an episode of preterm labor. However, a negative cervicovaginal fetal fibronectin test could be useful in identifying women who are not at risk for delivering within the next week, which could avoid unnecessary hospitalization and treatment. This review underscores the need to develop accurate tests for predicting preterm birth in twin gestations. Moreover, the use of interventions in these patients based on test results should be associated with the improvement of perinatal outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.