ArticleNature communications2014
Myocardium-derived angiopoietin-1 is essential for coronary vein formation in the developing heart.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 75 citations in OpenAlex.
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- Congenital Coronary Blood Vessel Anomalies: Animal Models and the Integration of Developmental Mechanisms.Advances in experimental medicine and biology · 2024Article
- The effects of treadmill exercise on brain angiogenesis in ovariectomized rats.Physiological reports · 2023Article
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- Cardiac inducing colonies halt fibroblast activation and induce cardiac/endothelial cells to move and expand via paracrine signaling.Molecular biology of the cell · 2022Article
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- Perinatal angiogenesis from pre-existing coronary vessels via DLL4-NOTCH1 signalling.Nature cell biology · 2021Article
- Proteomic Analysis of Estrogen-Mediated Enhancement of Mesenchymal Stem Cell-Induced Angiogenesis In Vivo.Cells · 2021Article
- Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor-endothelial cell crosstalk.Nature neuroscience · 2021Article
- Coronary vessel formation in development and disease: mechanisms and insights for therapy.Nature reviews. Cardiology · 2020Review
- The Formation of Coronary Vessels in Cardiac Development and Disease.Cold Spring Harbor perspectives in biology · 2020Review
- O-linked β-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1.PLoS genetics · 2020Article
- Indexes of Angiogenic Activation in Myocardial Samples of Patients with Advanced Chronic Heart Failure.Medicina (Kaunas, Lithuania) · 2019Article
- Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration.Science advances · 2019Article
- Coronary Vasculature in Cardiac Development and Regeneration.Journal of cardiovascular development and disease · 2018Review
- Arterial Venous Differentiation for Vascular Bioengineering.Annual review of biomedical engineering · 2018Review
- Cardiomyocyte-Endothelial Cell Interactions in Cardiac Remodeling and Regeneration.Frontiers in cardiovascular medicine · 2018Review
- HSPB7 is indispensable for heart development by modulating actin filament assembly.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
26 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The origin and developmental mechanisms underlying coronary vessels are not fully elucidated. Here we show that myocardium-derived angiopoietin-1 (Ang1) is essential for coronary vein formation in the developing heart. Cardiomyocyte-specific Ang1 deletion results in defective formation of the subepicardial coronary veins, but had no significant effect on the formation of intramyocardial coronary arteries. The endothelial cells (ECs) of the sinus venosus (SV) are heterogeneous population, composed of APJ-positive and APJ-negative ECs. Among these, the APJ-negative ECs migrate from the SV into the atrial and ventricular myocardium in Ang1-dependent manner. In addition, Ang1 may positively regulate venous differentiation of the subepicardial APJ-negative ECs in the heart. Consistently, in vitro experiments show that Ang1 indeed promotes venous differentiation of the immature ECs. Collectively, our results indicate that myocardial Ang1 positively regulates coronary vein formation presumably by promoting the proliferation, migration and differentiation of immature ECs derived from the SV.
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