ArticleBehavioural brain research2014
Temporally-patterned deep brain stimulation in a mouse model of multiple traumatic brain injury.
Article in Behavioural brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study.Nature medicine · 2023Trial
- Neuromodulation techniques in traumatic brain injury: a narrative review of the current state.Acta neurologica Belgica · 2025Review
- Electrical stimulation methods and protocols for the treatment of traumatic brain injury: a critical review of preclinical research.Journal of neuroengineering and rehabilitation · 2023Review
- Selective activation of central thalamic fiber pathway facilitates behavioral performance in healthy non-human primates.Scientific reports · 2021Article
- The Appearance Order of Varying Intervals Introduces Extra Modulation Effects on Neuronal Firing Through Non-linear Dynamics of Sodium Channels During High-Frequency Stimulations.Frontiers in neuroscience · 2020Article
- Small Changes in Inter-Pulse-Intervals Can Cause Synchronized Neuronal Firing During High-Frequency Stimulations in Rat Hippocampus.Frontiers in neuroscience · 2019Article
- Modulation of Theta-Band Local Field Potential Oscillations Across Brain Networks With Central Thalamic Deep Brain Stimulation to Enhance Spatial Working Memory.Frontiers in neuroscience · 2019Article
- Temporal Pattern of Electrical Stimulation is a New Dimension of Therapeutic Innovation.Current opinion in biomedical engineering · 2018Article
- Deep brain stimulation for the treatment of disorders of consciousness and cognition in traumatic brain injury patients: a review.Neurosurgical focus · 2018Review
- Molecular profiling of reticular gigantocellularis neurons indicates that eNOS modulates environmentally dependent levels of arousal.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Investigating the impact of electrical stimulation temporal distribution on cortical network responses.BMC neuroscience · 2017Article
- Role of Thalamus in Recovery of Traumatic Brain Injury.Journal of neurosciences in rural practice · 2016Review
- Robust modulation of arousal regulation, performance, and frontostriatal activity through central thalamic deep brain stimulation in healthy nonhuman primates.Journal of neurophysiology · 2016Article
- Central thalamic deep brain stimulation to support anterior forebrain mesocircuit function in the severely injured brain.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
- Hippocampal Neurophysiologic Changes after Mild Traumatic Brain Injury and Potential Neuromodulation Treatment Approaches.Frontiers in systems neuroscience · 2016Review
- Deep Brain Stimulation: Expanding Applications.Neurologia medico-chirurgica · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
We report that mice with closed-head multiple traumatic brain injury (TBI) show a decrease in the motoric aspects of generalized arousal, as measured by automated, quantitative behavioral assays. Further, we found that temporally-patterned deep brain stimulation (DBS) can increase generalized arousal and spontaneous motor activity in this mouse model of TBI. This arousal increase is input-pattern-dependent, as changing the temporal pattern of DBS can modulate its effect on motor activity. Finally, an extensive examination of mouse behavioral capacities, looking for deficits in this model of TBI, suggest that the strongest effects of TBI in this model are found in the initiation of any kind of movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.