ArticleBritish journal of cancer2014
A proposed new method for assessing the pathological response to chemotherapy in resected colorectal liver metastases.
Article in British journal of cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Liver resection following neoadjuvant immunotherapy: a single center retrospective study.Updates in surgery · 2026Article
- Exploratory analysis of tumor budding density in resected synchronous and metachronous colorectal liver metastases.Frontiers in oncology · 2026Article
- Integrative Predictive Nomograms for Treatment Decision-Making in Resectable Synchronous Colorectal Liver Metastases.Journal of Cancer · 2025Article
- Molecular profiling and patient selection for the multimodal approaches for patients with resectable colorectal liver metastases.Hepatobiliary surgery and nutrition · 2024Review
- Combined Resection Approaches: Decision Making for Synchronous Resection, Timing of Staged Intervention to Optimize Outcome.Clinics in colon and rectal surgery · 2024Review
- Treatment response assessment to chemotherapy with bevacizumab for colorectal liver metastasis by contrast-enhanced ultrasound.Quantitative imaging in medicine and surgery · 2024Article
- The Pathologic Complete Response Ratio of Liver Metastases Represents a Valuable Prognostic Indicator.Pathology oncology research : POR · 2022Article
- Histological tumor response assessment in colorectal liver metastases after neoadjuvant chemotherapy: impact of the variation in tumor regression grading and peritumoral lymphocytic infiltration.Journal of Cancer · 2019Article
- Long-term survival and cure model following liver resection for breast cancer metastases.Breast cancer research and treatment · 2018Article
- Rare genetic heterogeneity within single tumor discovered for the first time in colorectal liver metastases after liver resection.Oncotarget · 2018Article
- Impact of homogeneous pathologic response to preoperative chemotherapy in patients with multiple colorectal liver metastases.World journal of gastroenterology · 2017Article
- Scoring histological regression in peritoneal carcinomatosis: does it count?Pleura and peritoneum · 2016Article
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11 authors.
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Abstract
backgroundPathological response (PR) to preoperative chemotherapy for colorectal liver metastases (CLM) is recognised as a prognostic factor of outcome. However, the optimal system to assess this parameter is still debated. This study focuses on current methods and proposes a possibly better method for assessing PR.
methodsAmong 223 patients resected for CLM between 2004 and 2011, after more than three cycles of chemotherapy, the percentage of tumour cells, necrosis and fibrosis, and the tumour regression grade were assessed for each of 802 nodules. Pathological response was evaluated according to validated methods and their combinations. A new method combined the percentage of tumour cells and the size of all nodules as follows: , where n is each separate nodule, % is the percentage of remaining tumour cells within nodule n (%) and s is the size of nodule n (cm).The prognostic value of each method was calculated.
resultsAfter a median follow-up of 47 months (3-106), the cumulative 5-year overall survival rate after liver resection was 59%. The proposed method categorised as follows: 0 residual tumour; 0.1-6-cm residual tumour; >6-cm residual tumour, and necrosis rate >50% stratified prognosis (P=0.0027; P=0.02), while the other methods did not. At multivariate analysis, our method remained an independent predictor of outcome (P=0.001).
conclusionsCombining the percentage of tumour cells multiplied by the size of each separate tumour seems to be a better method for assessing PR. External validation is required.
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