ArticlePloS one2014
Differential expression of heat shock transcription factors and heat shock proteins after acute and chronic heat stress in laying chickens (Gallus gallus).
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed, 169 citations in OpenAlex.
- Dietary supplementation with methionine and/or turmeric oil enhances carcass cuts, economics, meat quality, and antioxidant status in broilers: insights into DNA methyltransferase transcripts.Tropical animal health and production · 2026Article
- A methyl donor and an essential oil: Performance, economic efficiency, serum biochemistry, histomorphometry, and appetite/growth-related gene expression in broilers.Veterinary research communications · 2026Article
- Genome-Wide Identification, Expression Analysis ofPlants (Basel, Switzerland) · 2026Article
- The Genetic and Morphological Basis of Local Adaptation to Elevational Extremes in an Alpine Finch.Ecology and evolution · 2026Article
- Integrative transcriptomics and metabolomics reveal neuroendocrine-lipid crosstalk and adenosine signaling in broiler under heat stress.BMC genomics · 2025Article
- Impact of Thermal Manipulation of Broiler Eggs on Growth Performance, Splenic Inflammatory Cytokine Levels, and Heat Shock Protein Responses to Post-Hatch Lipopolysaccharide (LPS) Challenge.Animals : an open access journal from MDPI · 2025Article
- Major Oxidative and Antioxidant Mechanisms During Heat Stress-Induced Oxidative Stress in Chickens.Antioxidants (Basel, Switzerland) · 2025Review
- Review
- Heat shock protein gene expression varies among populations but does not strongly track recent environmental conditions: implications for biomarker development.Frontiers in physiology · 2025Article
- Prenatal Acoustic Signals Influence Nestling Heat Shock Protein Response to Heat and Heterophil-to-Lymphocyte Ratio in a Desert Bird.International journal of molecular sciences · 2024Article
- HSP90 Enhances Mitophagy to Improve the Resistance of Car-Diomyocytes to Heat Stress in Wenchang Chickens.International journal of molecular sciences · 2024Article
- Synergistic impact of Chlorella vulgaris, zinc oxide- and/or selenium nanoparticles dietary supplementation on broiler's growth performance, antioxidant and blood biochemistry.Tropical animal health and production · 2024Article
- Neonatal α-Ketoglutaric Acid Gavage May Potentially Alleviate Acute Heat Stress by Modulating Hepatic Heat Shock Protein 90 and Improving Blood Antioxidant Status of Broilers.Animals : an open access journal from MDPI · 2024Article
- Robust identification of interactions between heat-stress responsive genes in the chicken brain using Bayesian networks and augmented expression data.Scientific reports · 2024Article
- Expression patterns of heat-shock genes during stopover and the trade-off between refueling and stress response in a passerine migrant.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Genomic analysis of Nigerian indigenous chickens reveals their genetic diversity and adaptation to heat-stress.Scientific reports · 2024Article
- Article
- Effect of dietary betaine supplementation on the liver transcriptome profile in broiler chickens under heat stress conditions.Animal bioscience · 2023Article
- Influence of different heat stress models on nutrient digestibility and markers of stress, inflammation, lipid, and protein metabolism in broilers.Poultry science · 2023Article
- The Influence of Heat Stress on Chicken Immune System and Mitigation of Negative Impacts by Baicalin and Baicalein.Animals : an open access journal from MDPI · 2023Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat stress due to high environmental temperature negatively influences animal performances. To better understand the biological impact of heat stress, laying broiler breeder chickens were subjected either to acute (step-wisely increasing temperature from 21 to 35°C within 24 hours) or chronic (32°C for 8 weeks) high temperature exposure. High temperature challenges significantly elevated body temperature of experimental birds (P<0.05). However, oxidation status of lipid and protein and expression of heat shock transcription factors (HSFs) and heat shock proteins (HSPs) 70 and 90 were differently affected by acute and chronic treatment. Tissue-specific responses to thermal challenge were also found among heart, liver and muscle. In the heart, acute heat challenge affected lipid oxidation (P = 0.05) and gene expression of all 4 HSF gene expression was upregulated (P<0.05). During chronic heat treatment, the HSP 70 mRNA level was increased (P<0.05) and HSP 90 mRNA (P<0.05) was decreased. In the liver, oxidation of protein was alleviated during acute heat challenge (P<0.05), however, gene expression HSF2, 3 and 4 and HSP 70 were highly induced (P<0.05). HSP90 expression was increased by chronic thermal treatment (P<0.05). In the muscle, both types of heat stress increased protein oxidation, but HSFs and HSPs gene expression remained unaltered. Only tendencies to increase were observed in HSP 70 (P = 0.052) and 90 (P = 0.054) gene expression after acute heat stress. The differential expressions of HSF and HSP genes in different tissues of laying broiler breeder chickens suggested that anti-heat stress mechanisms might be provoked more profoundly in the heart, by which the muscle was least protected during heat stress. In addition to HSP, HSFs gene expression could be used as a marker during acute heat stress.
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