ArticlePloS one2014
Associations of HLA-A, -B and -DRB1 types with oral diseases in Swiss adults.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Association between HLA molecules and stage III/IV grade C periodontitis in a Moroccan population: A case-control study.Journal of advanced periodontology & implant dentistry · 2026Article
- Genome-wide association study of pulpal and apical diseases.Nature communications · 2025Article
- HLA-DRB1 alleles and salivary Streptococcus mutans colonization in a group of Swedish children.BMC oral health · 2025Article
- HLA Polymorphisms Linked to the Severity and Extent of Periodontitis in Patients with Type 1 Diabetes from a Brazilian Mixed Population.International journal of environmental research and public health · 2025Article
- Estimation and Correlation of Human Leukocyte Antigen-DR and Human Leukocyte Antigen-DQ in Children with and without Severe-early Childhood Caries: A Randomized Clinical Trial.International journal of clinical pediatric dentistry · 2024Article
- Human leukocyte antigens are associated with salivary level of active MMP-8.Clinical and experimental dental research · 2021Article
- Oral disorders in patients with newly diagnosed haematological diseases.Clinical oral investigations · 2020Article
- The complex pattern of genetic associations of leprosy with HLA class I and class II alleles can be reduced to four amino acid positions.PLoS pathogens · 2020Article
- Association betweenThe Journal of international medical research · 2020Article
- Dissociations of oral foci of infections with infectious complications and survival after haematopoietic stem cell transplantation.PloS one · 2019Article
- A haplotypic variant at the IRGM locus and rs11747270 are related to the susceptibility for chronic periodontitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018Article
- HLA Haplotypes and Genotypes Frequencies in Brazilian Chronic Periodontitis Patients.Mediators of inflammation · 2015Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human leukocyte antigens (HLA) are crucial components of host defense against microbial challenge but the associations of HLA types with oral infectious diseases have not been studied in detail. This prospective cross-sectional study examined associations of HLA-A, -B and -DRB1 types with common oral diseases in a healthy Swiss adult population. 257 subjects (107 m, 150 f, mean age: 43.5 yr; range: 21-58 yr) with known HLA-A, -B and -DRB1 profiles and comprehensive medical records were included. A thorough anamnesis was followed by oral examinations including saliva flow measurements, the DMFT score for cariological status, complete periodontal status with plaque and bleeding indexes as well as assessment of mucosal alterations and temporomandibular dysfunction (TMD). Student's t-test and Pearson chi-square test were utilized to compare the oral diseases between HLA positive and negative subjects. Bonferroni correction for multiple comparisons was used and PBonf<0.05 was considered statistically significant. HLA types -B15 (PBonf = 0.002), -B51 (PBonf = 0.02) and -DRB1*12 (PBonf = 0.02) were associated with less periodontal disease manifestations. HLA-A32 had a positive association with TMD dysfunction (PBonf = 0.012). No other statistically significant associations were observed. In conclusion, HLA types may contribute to the development of oral diseases in generally healthy Caucasian adults.
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