Evidence map›Paper›PMID 25071965›Full record

ArticleBiomedical optics express2014

Non-contact small animal fluorescence imaging system for simultaneous multi-directional angular-dependent data acquisition.

Jong Hwan Lee, Hyun Keol Kim, Chandhanarat Chandhanayingyong, Francis Young-In Lee, Andreas H Hielscher

Abstract read
In one paragraph

Article in Biomedical optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jong Hwan LeeDepartment of Biomedical Engineering, Columbia University, 351 Engineering Terrace Mudd building, 500 West 120th Street, New York, NY, 10027, USA.
Hyun Keol KimDepartment of Radiology, Columbia University Medical Center, 180 Fort Washington Avenue, New York, NY, 10032, USA.
Chandhanarat ChandhanayingyongDepartment of Orthopedic Surgery, Columbia University Medical Center, 650 West 168th Street, New York, NY, 10032, USA.
Francis Young-In LeeDepartment of Orthopedic Surgery, Columbia University Medical Center, 650 West 168th Street, New York, NY, 10032, USA.
Andreas H HielscherDepartment of Biomedical Engineering, Columbia University, 351 Engineering Terrace Mudd building, 500 West 120th Street, New York, NY, 10027, USA ; Department of Radiology, Columbia University Medical Center, 180 Fort Washington Avenue, New York, NY, 10032, USA ; Department of Electrical Engineering, Columbia University, 1300 S. W. Mudd Building, 500 West 120th Street, New York, NY, 10027, USA.

Funding

Optical Tomographic Imaging of Peripheral Arterial DiseaseR01HL115336 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HIELSCHER, ANDREAS H · 2013 to 2017
$2.5M
Small Animal Tomography System for Green Fluorescent Protein ImagingR33CA118666 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HIELSCHER, ANDREAS H · 2008 to 2011
$1.1M
NCI NIH HHS R33 CA118666NHLBI NIH HHS R01 HL115336
6 · The paper itself

Abstract

We present a novel non-contact small animal fluorescent molecular tomography (FMT) imaging system. At the heart of the system is a new mirror-based imaging head that was designed to provide 360-degree measurement data from an entire animal surface in one step. This imaging head consists of two conical mirrors, which considerably reduce multiple back reflections between the animal and mirror surfaces. These back reflections are common in existing mirror-based imaging heads and tend to degrade the quality of raw measurement data. In addition, the introduction of a novel ray-transfer operator allows for the inclusion of the angular dependent data in the image reconstruction process, which results in higher image resolution. We describe in detail the system design and implementation of the hardware components as well as the transport-theory-based image reconstruction algorithm. Using numerical simulations, measurements on a well-defined phantom and a live animal, we evaluate the system performance and show the advantages of our approach.

Indexed as

(170.0110) Imaging systems(170.6280) Spectroscopy, fluorescence and luminescence(170.6960) Tomography

Identifiers

PMID25071965
PMCPMC4102365

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.