Evidence map›Paper›PMID 25071943›Full record

ArticleBiomedical optics express2014

Noncontact quantitative biomechanical characterization of cardiac muscle using shear wave imaging optical coherence tomography.

Shang Wang, Andrew L Lopez, Yuka Morikawa, Ge Tao, Jiasong Li, Irina V Larina, James F Martin, Kirill V Larin

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 97 citations in OpenAlex.

  1. Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026
    Review
  2. Article
  3. Wave-based optical coherence elastography: The 10-year perspective.Progress in biomedical engineering (Bristol, England) · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shang WangDepartment of Biomedical Engineering, University of Houston, 3605 Cullen Blvd., Houston, Texas 77204-5060, USA.
Andrew L LopezDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Texas, USA.
Yuka MorikawaDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Texas, USA.
Ge TaoDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Texas, USA.
Jiasong LiDepartment of Biomedical Engineering, University of Houston, 3605 Cullen Blvd., Houston, Texas 77204-5060, USA.
Irina V LarinaDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Texas, USA.
James F MartinDepartment of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Texas, USA ; Texas Heart Institute, Houston, Texas 77030, USA.
Kirill V LarinDepartment of Biomedical Engineering, University of Houston, 3605 Cullen Blvd., Houston, Texas 77204-5060, USA ; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Texas, USA.
Baylor College of Medicine · USUniversity of Houston · US

Funding

Optical Coherence Elastography of the CorneaR01EY022362 · NEI · UNIVERSITY OF HOUSTON · PI Salavat R Aglyamov, Kirill V Larin · 2012 to 2026
$6.7M
Pitx2 in atrial fibrillationR01HL118761 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI MARTIN, JAMES F · 2014 to 2025
$6.1M
MicroRNAs in cleft lip and palateR01DE023177 · NIDCR · BAYLOR COLLEGE OF MEDICINE · PI MARTIN, JAMES F · 2013 to 2017
$2.8M
Biomechanics of early mammalian cardiogenesisR01HL120140 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LARINA, IRINA · 2013 to 2017
$2.0M
NEI NIH HHS R01 EY022362NHLBI NIH HHS R01 HL118761NHLBI NIH HHS R01 HL120140NIDCR NIH HHS R01 DE023177
6 · The paper itself

Abstract

We report on a quantitative optical elastographic method based on shear wave imaging optical coherence tomography (SWI-OCT) for biomechanical characterization of cardiac muscle through noncontact elasticity measurement. The SWI-OCT system employs a focused air-puff device for localized loading of the cardiac muscle and utilizes phase-sensitive OCT to monitor the induced tissue deformation. Phase information from the optical interferometry is used to reconstruct 2-D depth-resolved shear wave propagation inside the muscle tissue. Cross-correlation of the displacement profiles at various spatial locations in the propagation direction is applied to measure the group velocity of the shear waves, based on which the Young's modulus of tissue is quantified. The quantitative feature and measurement accuracy of this method is demonstrated from the experiments on tissue-mimicking phantoms with the verification using uniaxial compression test. The experiments are performed on ex vivo cardiac muscle tissue from mice with normal and genetically altered myocardium. Our results indicate this optical elastographic technique is useful as a noncontact tool to assist the cardiac muscle studies.

Indexed as

(170.4500) Optical coherence tomography(170.6935) Tissue characterization

Identifiers

PMID25071943
PMCPMC4102343
OpenAlexW1993126196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.