ReviewCraniomaxillofacial trauma & reconstruction2014
The Delay Phenomenon: A Compilation of Knowledge across Specialties.
Review in Craniomaxillofacial trauma & reconstruction, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 79 citations in OpenAlex.
- The Effect of Controlled Release Mixture of VEGF165 and Fibrin Sealant on Flap Preconditioning in a Rat Perforator Island Flap Model.Aesthetic plastic surgery · 2026Article
- The P-D-T anatomical classification system for supraclavicular artery perforator flap: technical optimization and clinical validation in 78 head and neck reconstructions.World journal of surgical oncology · 2026Article
- Article
- When microsurgery is not an option: staged delayed reverse sural artery flap with ischaemic preconditioning for limb salvage in an elderly patient with chronic post-traumatic osteomyelitis-a case report.Frontiers in surgery · 2026Article
- [Effects and mechanism of electroacupuncture stimulation on the survival of multi-territory perforator flaps in rats].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2025Article
- Role of Superficial Thoracoepigastric Vein in Delay Procedure of Deep Inferior Epigastric Artery Perforator Flap.Plastic and reconstructive surgery. Global open · 2025Article
- Human umbilical cord mesenchymal stem cells improve the survial of flaps by promoting angiogenesis in mice.European journal of medical research · 2025Article
- The trans-flap approach in secondary surgeries for severe open limb fractures.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- Exosomes in Skin Flap Survival: Unlocking Their Role in Angiogenesis and Tissue Regeneration.Biomedicines · 2025Review
- Near-infrared Spectroscopy-guided Flap Delay: For Flap Training and Timing of Pedicle Division.Journal of plastic and reconstructive surgery · 2025Article
- Optimizing flap surgery: the need for standardized surgical delay techniques and patient-specific approaches.Annals of translational medicine · 2024Article
- A New Convenient Incision Model of the Nipple-Sparing Mastectomy: Lateralized Parabolic Multiplanar Incision.Aesthetic plastic surgery · 2024Article
- Surgical delay in abdominal based flap surgery: a scoping review.Annals of translational medicine · 2024Article
- Nontopical Nitrates in Flap Perfusion and Delay Phenomenon.Plastic and reconstructive surgery. Global open · 2024Article
- Provisional resection of the nutrient artery in free anterolateral thigh flap debulking surgery.JPRAS open · 2024Article
- Standardized Pre-clinical Surgical Animal Model Protocol to Investigate the Cellular and Molecular Mechanisms of Ischemic Flap Healing.Biological procedures online · 2024Article
- Surgical delay increases the survival of expanded random-pattern flap in pediatric patients.Scientific reports · 2023Article
- Prospective Evaluation of a Universally Applied Laparoscopic Gastric Ischemic Preconditioning Protocol Prior to Esophagectomy with Comparison with Historical Controls.Annals of surgical oncology · 2023Article
- Application of a distant, direct, single-pedicle hinge flap for reconstruction of a circumferential cutaneous defect of the thoracic limb in a dog.The Canadian veterinary journal = La revue veterinaire canadienne · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective The purpose of this article is to review and integrate the available literature in different fields to gain a better understanding of the basic physiology and optimize vascular delay as a reconstructive surgery technique. Methods A broad search of the literature was performed using the Medline database. Two queries were performed using "vascular delay," a search expected to yield perspectives from the field of plastic and reconstructive surgery, and "ischemic preconditioning," (IPC) which was expected to yield research on the same topic in other fields. Results The combined searches yielded a total of 1824 abstracts. The "vascular delay" query yielded 76 articles from 1984 to 2011. The "ischemic preconditioning" query yielded 6534 articles, ranging from 1980 to 2012. The abstracts were screened for those from other specialties in addition to reconstructive surgery, analyzed potential or current uses of vascular delay in practice, or provided developments in understanding the pathophysiology of vascular delay. 70 articles were identified that met inclusion criteria and were applicable to vascular delay or ischemic preconditioning. Conclusion An understanding of IPC's implementation and mechanisms in other fields has beneficial implications for the field of reconstructive surgery in the context of the delay phenomenon. Despite an incomplete model of IPC's pathways, the anti-oxidative, anti-apoptotic and anti-inflammatory benefits of IPC are well recognized. The activation of angiogenic genes through IPC could allow for complex flap design, even in poorly vascularized regions. IPC's promotion of angiogenesis and reduction of endothelial dysfunction remain most applicable to reconstructive surgery in reducing graft-related complications and flap failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.