Evidence map›Paper›PMID 25071822›Full record

ReviewFrontiers in genetics2014

Identification of structural variation in mouse genomes.

Thomas M Keane, Kim Wong, David J Adams, Jonathan Flint, Alexandre Reymond, Binnaz Yalcin

Abstract readReview
In one paragraph

Review in Frontiers in genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. The role of copy-number variation in the reinforcement of sexual isolation between the two European subspecies of the house mouse.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020
    Article
  4. Article
  5. Connecting genome structural variation with complex traits in crop plants.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Mouse genome annotation by the RefSeq project.Mammalian genome : official journal of the International Mammalian Genome Society · 2015
    Article
  12. Creating reference gene annotation for the mouse C57BL6/J genome assembly.Mammalian genome : official journal of the International Mammalian Genome Society · 2015
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Thomas M KeaneWellcome Trust Sanger Institute Hinxton, Cambridge, UK.
Kim WongWellcome Trust Sanger Institute Hinxton, Cambridge, UK.
David J AdamsWellcome Trust Sanger Institute Hinxton, Cambridge, UK.
Jonathan FlintWellcome Trust Centre for Human Genetics Oxford, UK.
Alexandre ReymondCenter for Integrative Genomics, University of Lausanne Lausanne, Switzerland.
Binnaz YalcinCenter for Integrative Genomics, University of Lausanne Lausanne, Switzerland ; Institute of Genetics and Molecular and Cellular Biology Illkirch, France.

Funding

Medical Research Council G0800024Medical Research Council MR/L007428/1
6 · The paper itself

Abstract

Structural variation is variation in structure of DNA regions affecting DNA sequence length and/or orientation. It generally includes deletions, insertions, copy-number gains, inversions, and transposable elements. Traditionally, the identification of structural variation in genomes has been challenging. However, with the recent advances in high-throughput DNA sequencing and paired-end mapping (PEM) methods, the ability to identify structural variation and their respective association to human diseases has improved considerably. In this review, we describe our current knowledge of structural variation in the mouse, one of the prime model systems for studying human diseases and mammalian biology. We further present the evolutionary implications of structural variation on transposable elements. We conclude with future directions on the study of structural variation in mouse genomes that will increase our understanding of molecular architecture and functional consequences of structural variation.

Indexed as

array comparative genome hybridization (aCGH)Heterogeneous Stock (HS)inbred strains of micenext-generation sequencing (NGS)paired-end mapping (PEM)Sanger Mouse Genomes Projectstructural variation (SV)

Identifiers

PMID25071822
PMCPMC4079067

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.