ArticleFrontiers in physiology2014
Control elements targeting Tgfb3 expression to the palatal epithelium are located intergenically and in introns of the upstream Ift43 gene.
Article in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- Periderm Fate during Palatogenesis: TGF-β and Periderm Dedifferentiation.Journal of dental research · 2023Article
- Canonical Wnt signaling is not required forFrontiers in physiology · 2023Article
- Disruption of theFrontiers in cell and developmental biology · 2023Article
- Mouse models in palate development and orofacial cleft research: Understanding the crucial role and regulation of epithelial integrity in facial and palate morphogenesis.Current topics in developmental biology · 2022Article
- Wnt signaling in orofacial clefts: crosstalk, pathogenesis and models.Disease models & mechanisms · 2019Review
- Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion.Developmental biology · 2018Article
- Molecular and Cellular Mechanisms of Palate Development.Journal of dental research · 2017Review
- Article
- Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development.Developmental biology · 2015Article
- Cellular and Molecular Mechanisms of Palatogenesis.Current topics in developmental biology · 2015Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Tgfb3 is strongly and specifically expressed in the epithelial tips of pre-fusion palatal shelves where it plays a critical non-redundant role in palatal fusion in both medial edge epithelial (MEE) cells and in a thin layer of flattened peridermal cells that covers the MEE. It is not known how Tgfb3 expression is regulated in these specific cell types. Using comparative genomics and transgenic reporter assays, we have identified cis-regulatory elements that could control Tgfb3 expression during palatogenesis. Our results show that a 61-kb genomic fragment encompassing the Tgfb3 gene drives remarkably specific reporter expression in the MEE and adjacent periderm. Within this fragment, we identified two small, non-coding, evolutionarily conserved regions in intron 2 of the neighboring Ift43 gene, and a larger region in the intervening sequence between the Ift43 and Tgfb3 genes, each of which could target reporter activity to the tips of pre-fusion/fusing palatal shelves. Identification of the cis-regulatory sequences controlling spatio-temporal Tgfb3 expression in palatal shelves is a key step toward understanding upstream regulation of Tgfb3 expression during palatogenesis and should enable the development of improved tools to investigate palatal epithelial fusion.
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Registered trials
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