ArticleFrontiers in aging neuroscience2014
A neurodegenerative vascular burden index and the impact on cognition.
Article in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Blood-Brain Barrier Crossing Renin-Angiotensin Drugs and Cognition in the Elderly: A Meta-Analysis.Hypertension (Dallas, Tex. : 1979) · 2021Pooled it
- Urinary kallidinogenase for the treatment of cerebral arterial stenosis.Drug design, development and therapy · 2015Trial
- Vascular Risk Factors and Cognition in Multiple System Atrophy.Frontiers in neuroscience · 2021Article
- Carotid atherosclerosis promotes the progression of Alzheimer's disease: A three-year prospective study.Experimental and therapeutic medicine · 2017Article
- Brain activation in frontotemporal and Alzheimer's dementia: a functional near-infrared spectroscopy study.Alzheimer's research & therapy · 2016Article
- Cerebral Perfusion Enhancing Interventions: A New Strategy for the Prevention of Alzheimer Dementia.Brain pathology (Zurich, Switzerland) · 2016Review
- Pharmacologically-induced neurovascular uncoupling is associated with cognitive impairment in mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2015Article
- Subclinical atherosclerosis and increased risk of hearing impairment.Atherosclerosis · 2015Article
- Age and Vascular Burden Determinants of Cortical Hemodynamics Underlying Verbal Fluency.PloS one · 2015Article
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A wide range of vascular burden factors has been identified to impact vascular function and structure as indicated by carotid intima-media thickness (IMT). On the basis of their impact on IMT, vascular factors may be selected and clustered in a vascular burden index (VBI). Since many vascular factors increase the risk of Alzheimer's disease (AD), a multifactorial neurodegenerative VBI may be related to early pathological processes in AD and cognitive decline in its preclinical stages. We investigated an elderly cohort at risk for neurodegeneration (TREND study, n = 1102) for the multifactorial influence of vascular burden factors on IMT measured by ultrasound. To create a VBI for this cohort, vascular factors and their definitions (considering medical history, medication, and/or blood marker data) were selected based on their statistical effects on IMT in multiple regressions including age and sex. The impact of the VBI on cognitive performance was assessed using the Trail-Making Test (TMT) and the consortium to establish a registry for Alzheimer's disease (CERAD) neuropsychological battery. IMT was significantly predicted by age (standardized β = 0.26), sex (0.09; males > females) and the factors included in the VBI: obesity (0.18), hypertension (0.14), smoking (0.08), diabetes (0.07), and atherosclerosis (0.05), whereas other cardiovascular diseases or hypercholesterolemia were not significant. Individuals with 2 or more VBI factors compared to individuals without had an odds ratio of 3.17 regarding overly increased IMT ( ≥ 1.0 mm). The VBI showed an impact on executive control [log(TMT B-A), p = 0.047] and a trend toward decreased global cognitive function (CERAD total score, p = 0.057) independent of age, sex, and education. A VBI established on the basis of IMT may help to identify individuals with overly increased vascular burden linked to decreased cognitive function indicating neurodegenerative processes. The longitudinal study of this risk cohort will reveal the value of the VBI as prodromal marker for cognitive decline and AD.
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