ReviewFrontiers in aging neuroscience2014
Why AMD is a disease of ageing and not of development: mechanisms and insights.
Review in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- CETP/LPL/LIPC gene polymorphisms and susceptibility to age-related macular degeneration.Scientific reports · 2015Pooled it
- The Association of Dietary Patterns with Age-Related Macular Degeneration in a Multiethnic Older Singaporean Population.Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde · 2026Article
- N-acetyl-l-cysteine ethyl ester (NACET) induces the transcription factor NRF2 and prevents retinal aging and diabetic retinopathy.Redox biology · 2025Article
- A study of the relationship between cytokine levels and the response to anti-VEGF therapy in polypoid choroidal vasculopathy with different choroidal thicknesses.Frontiers in endocrinology · 2023Article
- Associations of Tumor Necrosis Factor-Alpha Gene PolymorphismsLife (Basel, Switzerland) · 2022Article
- Modulated anti-VEGF therapy under the influence of lipid metabolizing proteins in Age related macular degeneration: a pilot study.Scientific reports · 2022Article
- Effect of Retinal Injury Induced by Laser Photocoagulation on Visuospatial Memory in Mouse Model.Journal of neurosciences in rural practice · 2021Article
- Does epigenetics have a role in age related macular degeneration and diabetic retinopathy?Genes & diseases · 2021Review
- Article
- Trends of Hypertension and Neurological Diseases in India: A Nationwide Survey Reporting the Distribution Across Geographical Areas.Annals of neurosciences · 2020Article
- Depression in High-Risk Type 2 Diabetes Adults.Annals of neurosciences · 2020Article
- Physical Activity Patterns in India Stratified by Zones, Age, Region, BMI and Implications for COVID-19: A Nationwide Study.Annals of neurosciences · 2020Article
- Prevalence of Obesity in India and Its Neurological Implications: A Multifactor Analysis of a Nationwide Cross-Sectional Study.Annals of neurosciences · 2020Article
- Sleep Disorders in Individuals With High Risk for Diabetes in Indian Population.Annals of neurosciences · 2020Article
- Bioinformatical Analysis of miRNA-mRNA Interaction Network Underlying Macrophage Aging and Cholesterol-Responsive Difference between Young and Aged Macrophages.BioMed research international · 2020Article
- Prevalence of Diabetes and Its Determinants in the Young Adults Indian Population-Call for Yoga Intervention.Frontiers in endocrinology · 2020Article
- Cathepsin B pH-Dependent Activity Is Involved in Lysosomal Dysregulation in Atrophic Age-Related Macular Degeneration.Oxidative medicine and cellular longevity · 2019Article
- CCL2 single nucleotide polymorphism of rs1024611 implicates prominence of inflammatory cascade by univariate modeling in Indian AMD.PloS one · 2018Article
- Shared genetic variants for polypoidal choroidal vasculopathy and typical neovascular age-related macular degeneration in East Asians.Journal of human genetics · 2017Article
- Key drivers of visual acuity gains in neovascular age-related macular degeneration in real life: findings from the AURA study.The British journal of ophthalmology · 2016Observational
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ageing disorders can be defined as the progressive and cumulative outcome of several defective cellular mechanisms as well as metabolic pathways, consequently resulting in degeneration. Environment plays an important role in its pathogenesis. In contrast, developmental disorders arise from inherited mutations and usually the role of environmental factors in development of disease is minimal. Age related macular degeneration (AMD) is one such retinal degenerative disorder which starts with the progression of age. Metabolism plays an important role in initiation of such diseases of ageing. Cholesterol metabolism and their oxidized products like 7-ketocholesterol have been shown to adversely impact retinal pigment epithelium (RPE) cells. These molecules can initiate mitochondrial apoptotic processes and also influence the complements factors and expression of angiogenic proteins like VEGF etc. In this review we highlight why and how AMD is an ageing disorder and not a developmental disease substantiated by disrupted cholesterol metabolism common to several age related diseases.
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