ArticleFrontiers in aging neuroscience2014
Studying variability in human brain aging in a population-based German cohort-rationale and design of 1000BRAINS.
Article in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 3 of them syntheses that pooled it.
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Who cites it
78 citing papers in PubMed, 3 syntheses or guidelines pooled it, 133 citations in OpenAlex.
- Neuroanatomical and psychological considerations in temporal lobe epilepsy.Frontiers in neuroanatomy · 2022Pooled it
- Genetic factors influencing a neurobiological substrate for psychiatric disorders.Translational psychiatry · 2021Pooled it
- The Right Dorsal Premotor Mosaic: Organization, Functions, and Connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2017Pooled it
- Multimodal investigation of the association between shift work and the brain in a population-based sample of older adults.Scientific reports · 2022Trial
- A longitudinal resource for mapping interindividual variation in the aging connectome.Scientific data · 2026Article
- Central pulsatile haemodynamics in COPD: a propensity score-matched evaluation of cohorts.ERJ open research · 2026Article
- Prediction of cognitive test scores: a comparison of brain structure, health, demographic, and cognitive data across adulthood.GeroScience · 2026Article
- Normative Modeling of Static and Dynamic Functional Connectivity.bioRxiv : the preprint server for biology · 2026Article
- Cross-sectional and longitudinal functional network alterations associated with subthreshold depressive symptoms in healthy older adults.Frontiers in aging neuroscience · 2026Article
- Brain age gap as predictor of disease progression in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- An open, longitudinal resource for mapping interindividual variation in the aging connectome.medRxiv : the preprint server for health sciences · 2025Article
- Systematic Review and Meta-analysis of AI-driven MRI Motion Artifact Detection and Correction.ArXiv · 2025Article
- Linking Individual Variability of Multi-modal Connectivity, Lifestyle, Psycho-Social Factors and Cognition in Older Adults.Aging and disease · 2025Article
- Atrophy related neuroimaging biomarkers for neurological and cognitive function in Wilson disease.Neurological research and practice · 2025Article
- Effective workflow from multimodal MRI data to model-based prediction.Scientific reports · 2025Article
- Are older adults more deceived by false advertising? Evidence from intra- and inter-brain connectivity in the prefrontal cortex during face-to-face deceptive sales.Social cognitive and affective neuroscience · 2025Article
- Article
- Structural Connectivity Differences Reflect Microstructural Heterogeneity of the Human Insular Cortex.Human brain mapping · 2025Article
- Prediction of Verbal Abilities From Brain Connectivity Data Across the Lifespan Using a Machine Learning Approach.Human brain mapping · 2025Article
- Predicting response speed and age from task-evoked effective connectivity.Network neuroscience (Cambridge, Mass.) · 2025Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
26 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ongoing 1000 brains study (1000BRAINS) is an epidemiological and neuroscientific investigation of structural and functional variability in the human brain during aging. The two recruitment sources are the 10-year follow-up cohort of the German Heinz Nixdorf Recall (HNR) Study, and the HNR MultiGeneration Study cohort, which comprises spouses and offspring of HNR subjects. The HNR is a longitudinal epidemiological investigation of cardiovascular risk factors, with a comprehensive collection of clinical, laboratory, socioeconomic, and environmental data from population-based subjects aged 45-75 years on inclusion. HNR subjects underwent detailed assessments in 2000, 2006, and 2011, and completed annual postal questionnaires on health status. 1000BRAINS accesses these HNR data and applies a separate protocol comprising: neuropsychological tests of attention, memory, executive functions and language; examination of motor skills; ratings of personality, life quality, mood and daily activities; analysis of laboratory and genetic data; and state-of-the-art magnetic resonance imaging (MRI, 3 Tesla) of the brain. The latter includes (i) 3D-T1- and 3D-T2-weighted scans for structural analyses and myelin mapping; (ii) three diffusion imaging sequences optimized for diffusion tensor imaging, high-angular resolution diffusion imaging for detailed fiber tracking and for diffusion kurtosis imaging; (iii) resting-state and task-based functional MRI; and (iv) fluid-attenuated inversion recovery and MR angiography for the detection of vascular lesions and the mapping of white matter lesions. The unique design of 1000BRAINS allows: (i) comprehensive investigation of various influences including genetics, environment and health status on variability in brain structure and function during aging; and (ii) identification of the impact of selected influencing factors on specific cognitive subsystems and their anatomical correlates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.