ArticleFrontiers in aging neuroscience2014
Correlations between Limbic White Matter and Cognitive Function in Temporal-Lobe Epilepsy, Preliminary Findings.
Article in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Neuropsychological correlations with fornix and hippocampus in temporal lobe epilepsy demonstrated with diffusion tensor imaging.Epilepsia open · 2026Article
- Article
- Early region-specific impact of adjuvant radiation therapy on cognition and quality of life in adult patients with primary brain tumors.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- DTI Connectometry Analysis Reveals White Matter Changes in Cognitively Impaired World Trade Center Responders at Midlife.Journal of Alzheimer's disease : JAD · 2022Article
- A ketogenic supplement improves white matter energy supply and processing speed in mild cognitive impairment.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- Contributions of Imaging to Neuromodulatory Treatment of Drug-Refractory Epilepsy.Brain sciences · 2020Review
- Cognitive slowing and its underlying neurobiology in temporal lobe epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Article
- Psychomotor slowing is associated with anomalies in baseline and prospective large scale neural networks in youth with epilepsy.NeuroImage. Clinical · 2018Article
- White Matter Integrity Declined Over 6-Months, but Dance Intervention Improved Integrity of the Fornix of Older Adults.Frontiers in aging neuroscience · 2017Article
- Graph theory and cognition: A complementary avenue for examining neuropsychological status in epilepsy.Epilepsy & behavior : E&B · 2016Review
- Mapping the landscape of cognitive development in children with epilepsy.Cortex; a journal devoted to the study of the nervous system and behavior · 2015Article
- White matter in temporal lobe epilepsy: clinico-pathological correlates of water diffusion abnormalities.Quantitative imaging in medicine and surgery · 2015Review
- What does diffusion tensor imaging (DTI) tell us about cognitive networks in temporal lobe epilepsy?Quantitative imaging in medicine and surgery · 2015Review
- Quantitative MRI in refractory temporal lobe epilepsy: relationship with surgical outcomes.Quantitative imaging in medicine and surgery · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The limbic system is presumed to have a central role in cognitive performance, in particular memory. The purpose of this study was to investigate the relationship between limbic white matter microstructure and neuropsychological function in temporal-lobe epilepsy (TLE) patients using diffusion tensor imaging (DTI). Twenty-one adult TLE patients, including 7 non-lesional (nlTLE) and 14 with unilateral mesial temporal sclerosis (uTLE), were studied with both DTI and hippocampal T2 relaxometry. Correlations were performed between fractional anisotropy (FA) of the bilateral fornix and cingulum, hippocampal T2, neuropsychological tests. Positive correlations were observed in the whole group for the left fornix and processing speed index. In contrast, memory tests did not show significant correlations with DTI findings. Subgroup analysis demonstrated an association between the left fornix and processing speed in nlTLE but not uTLE. No correlations were observed between hippocampal T2 and test scores in either the TLE group as a whole or after subgroup analysis. Our findings suggest that integrity of the left fornix specifically is an important anatomical correlate of cognitive function in TLE patients, in particular patients with nlTLE.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.