ArticleFrontiers in synaptic neuroscience2014
LTD expression is independent of glutamate receptor subtype.
Article in Frontiers in synaptic neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Overnight neuronal plasticity and adaptation to emotional distress.Nature reviews. Neuroscience · 2024Review
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- The Shaping of AMPA Receptor Surface Distribution by Neuronal Activity.Frontiers in synaptic neuroscience · 2022Review
- Persistent sexually dimorphic effects of adolescent THC exposure on hippocampal synaptic plasticity and episodic memory in rodents.Neurobiology of disease · 2022Article
- Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.Pharmacological reviews · 2021Review
- Phosphorylation-Dependent Regulation of CaFrontiers in synaptic neuroscience · 2020Article
- Developmental Changes of Glutamate and GABA Receptor Densities in Wistar Rats.Frontiers in neuroanatomy · 2019Article
- Functional organization of postsynaptic glutamate receptors.Molecular and cellular neurosciences · 2018Review
- Glutamate receptor GluA1 subunit is implicated in capsaicin induced modulation of amygdala LTP but not LTD.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Hippocampal Long-Term Depression in the Presence of Calcium-Permeable AMPA Receptors.Frontiers in synaptic neuroscience · 2018Article
- The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning.Nature neuroscience · 2018Article
- Synaptic homeostasis requires the membrane-proximal carboxy tail of GluA2.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning.Nature neuroscience · 2017Article
- AMPA GluA1-flip targeted oligonucleotide therapy reduces neonatal seizures and hyperexcitability.PloS one · 2017Article
- Synaptic AMPA receptor composition in development, plasticity and disease.Nature reviews. Neuroscience · 2016Review
- Basal levels of AMPA receptor GluA1 subunit phosphorylation at threonine 840 and serine 845 in hippocampal neurons.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity.Frontiers in cellular neuroscience · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term depression (LTD) is a form of synaptic plasticity that plays a major role in the activity-dependent reshaping of synaptic transmission. LTD is expressed as a decrease in synaptic AMPA receptor number, though the exact mechanism remains controversial. Several lines of evidence have suggested necessary roles for both the GluA1 and GluA2 subunits, and specifically certain interactions with their cytoplasmic tails. However, it is unclear if either GluA1 or GluA2 are absolutely required for LTD. We tested this hypothesis using constitutive knock-outs and single-cell molecular replacement of AMPA receptor subunits in mouse hippocampus. We found that neither GluA1 or GluA2 are required for normal expression of LTD, and indeed a normal decrease in synaptic transmission was observed in cells in which all endogenous AMPA receptors have been replaced by kainate receptors. Thus, LTD does not require removal of specific AMPA receptor subunits, but likely involves a more general modification of the synapse and its ability to anchor a broad range of receptor proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.