ArticleFrontiers in computational neuroscience2014
Memory consolidation from seconds to weeks: a three-stage neural network model with autonomous reinstatement dynamics.
Article in Frontiers in computational neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Latent persistence in fMRI dynamics during human memory consolidation.Neuroimage. Reports · 2026Article
- Learning, sleep replay and consolidation of contextual fear memories: A neural network model.PLoS computational biology · 2026Article
- A dynamic attractor network model of memory formation, reinforcement and forgetting.PLoS computational biology · 2023Article
- Article
- Anteromedial Thalamus Gates the Selection & Stabilization of Long-Term Memories.bioRxiv : the preprint server for biology · 2023Article
- Stochastic consolidation of lifelong memory.Scientific reports · 2022Article
- Coordinated hippocampal-thalamic-cortical communication crucial for engram dynamics underneath systems consolidation.Nature communications · 2022Article
- Neural mechanisms of attending to items in working memory.Neuroscience and biobehavioral reviews · 2019Review
- A Spiking Working Memory Model Based on Hebbian Short-Term Potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A simplified computational memory model from information processing.Scientific reports · 2016Article
- Limitation in monitoring depth of anesthesia: a case report.Journal of anesthesia · 2016Article
- Large-Scale Simulations of Plastic Neural Networks on Neuromorphic Hardware.Frontiers in neuroanatomy · 2016Article
- Functional Relevance of Different Basal Ganglia Pathways Investigated in a Spiking Model with Reward Dependent Plasticity.Frontiers in neural circuits · 2016Article
- Working Memory: Maintenance, Updating, and the Realization of Intentions.Cold Spring Harbor perspectives in biology · 2015Review
- Neurocognitive Architecture of Working Memory.Neuron · 2015Review
- Reducing the computational footprint for real-time BCPNN learning.Frontiers in neuroscience · 2015Article
- Establishing Performance Indicators of Telemedicine-Based "On-Consultation Training" of Primary Care Doctors: An Innovation to Integrate Psychiatry at Primary Care.Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineArticle
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Declarative long-term memories are not created in an instant. Gradual stabilization and temporally shifting dependence of acquired declarative memories in different brain regions-called systems consolidation-can be tracked in time by lesion experiments. The observation of temporally graded retrograde amnesia (RA) following hippocampal lesions points to a gradual transfer of memory from hippocampus to neocortical long-term memory. Spontaneous reactivations of hippocampal memories, as observed in place cell reactivations during slow-wave-sleep, are supposed to drive neocortical reinstatements and facilitate this process. We propose a functional neural network implementation of these ideas and furthermore suggest an extended three-state framework that includes the prefrontal cortex (PFC). It bridges the temporal chasm between working memory percepts on the scale of seconds and consolidated long-term memory on the scale of weeks or months. We show that our three-stage model can autonomously produce the necessary stochastic reactivation dynamics for successful episodic memory consolidation. The resulting learning system is shown to exhibit classical memory effects seen in experimental studies, such as retrograde and anterograde amnesia (AA) after simulated hippocampal lesioning; furthermore the model reproduces peculiar biological findings on memory modulation, such as retrograde facilitation of memory after suppressed acquisition of new long-term memories-similar to the effects of benzodiazepines on memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.