ArticleFrontiers in systems neuroscience2014
Frequency-specific corticofugal modulation of the dorsal cochlear nucleus in mice.
Article in Frontiers in systems neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Characterization of three cholinergic inputs to the cochlear nucleus.Journal of chemical neuroanatomy · 2023Article
- Recurrent Circuits Amplify Corticofugal Signals and Drive Feedforward Inhibition in the Inferior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Top-Down Inference in the Auditory System: Potential Roles for Corticofugal Projections.Frontiers in neural circuits · 2020Review
- Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical Preference.Frontiers in systems neuroscience · 2019Article
- Article
- All the way from the cortex: a review of auditory corticosubcollicular pathways.Cerebellum (London, England) · 2015Review
- The olivocochlear reflex strength and cochlear sensitivity are independently modulated by auditory cortex microstimulation.Journal of the Association for Research in Otolaryngology : JARO · 2015Article
- Corticofugal modulation of peripheral auditory responses.Frontiers in systems neuroscience · 2015Review
- Imbalance of excitation and inhibition at threshold level in the auditory cortex.Frontiers in neural circuits · 2015Article
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Authors and funding
4 authors.
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Abstract
The primary auditory cortex (AI) modulates the sound information processing in the lemniscal subcortical nuclei, including the anteroventral cochlear nucleus (AVCN), in a frequency-specific manner. The dorsal cochlear nucleus (DCN) is a non-lemniscal subcortical nucleus but it is tonotopically organized like the AVCN. However, it remains unclear how the AI modulates the sound information processing in the DCN. This study examined the impact of focal electrical stimulation of AI on the auditory responses of the DCN neurons in mice. We found that the electrical stimulation induced significant changes in the best frequency (BF) of DCN neurons. The changes in the BFs were highly specific to the BF differences between the stimulated AI neurons and the recorded DCN neurons. The DCN BFs shifted higher when the AI BFs were higher than the DCN BFs and the DCN BFs shifted lower when the AI BFs were lower than the DCN BFs. The DCN BFs showed no change when the AI and DCN BFs were similar. Moreover, the BF shifts were linearly correlated to the BF differences. Thus, our data suggest that corticofugal modulation of the DCN is also highly specific to frequency information, similar to the corticofugal modulation of the AVCN. The frequency-specificity of corticofugal modulation does not appear limited to the lemniscal ascending pathway.
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