ArticleFrontiers in neuroanatomy2014
Combinatorial expression of Lef1, Lhx2, Lhx5, Lhx9, Lmo3, Lmo4, and Prox1 helps to identify comparable subdivisions in the developing hippocampal formation of mouse and chicken.
Article in Frontiers in neuroanatomy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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57 citing papers in PubMed, 113 citations in OpenAlex.
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- Dynamic expression of lamin B1 during adult neurogenesis in the vertebrate brain.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Cortical Type: The Basis for a Modern Neurodevelopmental Synthesis (Ontogeny, Phylogeny, Synaptic Connectivity) of the Human Cerebral Cortex.The Journal of comparative neurology · 2026Review
- Differences in Cajal-Retzius Cell Density and Postnatal Persistence Across Cortical Areas Revealed by a Novel Intersectional Genetic Labeling Approach.The Journal of comparative neurology · 2025Article
- Transcriptomic Analysis Corroborates the New Radial Model of the Mouse Pallial Amygdala.Biomolecules · 2025Article
- Dual inhibition of MAPK/ERK and BMP signaling induces entorhinal-like identity in mouse ESC-derived pallial progenitors.Stem cell reports · 2025Article
- The possibilities of conscious experience in light of the dual origin hypothesis of the neocortex.Neuroscience of consciousness · 2025Article
- Translational Insights From Cell Type Variation Across Amygdala Subnuclei in Rhesus Monkeys and Humans.The American journal of psychiatry · 2024Article
- Three-dimensional liquid metal-based neuro-interfaces for human hippocampal organoids.Nature communications · 2024Article
- Article
- Topography of inputs into the hippocampal formation of a food-caching bird.The Journal of comparative neurology · 2023Article
- An entorhinal-like region in food-caching birds.Current biology : CB · 2023Article
- Topography of inputs into the hippocampal formation of a food-caching bird.bioRxiv : the preprint server for biology · 2023Article
- An entorhinal-like region in food-caching birds.bioRxiv : the preprint server for biology · 2023Article
- Molecular biology of serotonergic systems in avian brains.Frontiers in molecular neuroscience · 2023Review
- Molecular Diversity of Neuron Types in the Salamander Amygdala and Implications for Amygdalar Evolution.Brain, behavior and evolution · 2023Article
- Anatomical and molecular features of the amygdalohippocampal transition area and its role in social and emotional behavior processes.Neuroscience and biobehavioral reviews · 2022Review
- The brain of the tree pangolin (Manis tricuspis). VIII. The subpallial telencephalon.The Journal of comparative neurology · 2022Article
- Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution.Science (New York, N.Y.) · 2022Article
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3 authors at 1 institution in 1 country.
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Abstract
We carried out a study of the expression patterns of seven developmental regulatory genes (Lef1, Lhx2, Lhx9, Lhx5, Lmo3, Lmo4, and Prox1), in combination with topological position, to identify the medial pallial derivatives, define its major subdivisions, and compare them between mouse and chicken. In both species, the medial pallium is defined as a pallial sector adjacent to the cortical hem and roof plate/choroid tela, showing moderate to strong ventricular zone expression of Lef1, Lhx2, and Lhx9, but not Lhx5. Based on this, the hippocampal formation (indusium griseum, dentate gyrus, Ammon's horn fields, and subiculum), the medial entorhinal cortex, and part of the amygdalo-hippocampal transition area of mouse appeared to derive from the medial pallium. In the chicken, based on the same position and gene expression profile, we propose that the hippocampus (including the V-shaped area), the parahippocampal area (including its caudolateral part), the entorhinal cortex, and the amygdalo-hippocampal transition area are medial pallial derivatives. Moreover, the combinatorial expression of Lef1, Prox1, Lmo4, and Lmo3 allowed the identification of dentate gyrus/CA3-like, CA1/subicular-like, and medial entorhinal-like comparable sectors in mouse and chicken, and point to the existence of mostly conserved molecular networks involved in hippocampal complex development. Notably, while the mouse medial entorhinal cortex derives from the medial pallium (similarly to the hippocampal formation, both being involved in spatial navigation and spatial memory), the lateral entorhinal cortex (involved in processing non-spatial, contextual information) appears to derive from a distinct dorsolateral caudal pallial sector.
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