ArticleFrontiers in neural circuits2014
Synaptic dynamics contribute to long-term single neuron response fluctuations.
Article in Frontiers in neural circuits, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Simultaneous encoding of sensory features: the role of multiplexing and noise in tactile perception and neural representation.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Predictable Fluctuations in Excitatory Synaptic Strength Due to Natural Variation in Presynaptic Firing Rate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Spontaneous and Perturbational Complexity in Cortical Cultures.Brain sciences · 2021Article
- Unique Features of Network Bursts Emerge From the Complex Interplay of Excitatory and Inhibitory Receptors in Rat Neocortical Networks.Frontiers in cellular neuroscience · 2019Article
- A Biohybrid Setup for Coupling Biological and Neuromorphic Neural Networks.Frontiers in neuroscience · 2019Article
- Article
- Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays.Journal of visualized experiments : JoVE · 2018Article
- Switching between internal and external modes: A multiscale learning principle.Network neuroscience (Cambridge, Mass.) · 2018Article
- Exogenous α-synuclein hinders synaptic communication in cultured cortical primary rat neurons.PloS one · 2018Article
- Closed Loop Experiment Manager (CLEM)-An Open and Inexpensive Solution for Multichannel Electrophysiological Recordings and Closed Loop Experiments.Frontiers in neuroscience · 2017Article
- Network burst activity in hippocampal neuronal cultures: the role of synaptic and intrinsic currents.Journal of neurophysiology · 2016Article
- Brief wide-field photostimuli evoke and modulate oscillatory reverberating activity in cortical networks.Scientific reports · 2016Article
- The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A.Cell reports · 2016Article
- Repeated stimulation of cultured networks of rat cortical neurons induces parallel memory traces.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- α-Synuclein strains cause distinct synucleinopathies after local and systemic administration.Nature · 2015Article
- A reconfigurable visual-programming library for real-time closed-loop cellular electrophysiology.Frontiers in neuroinformatics · 2015Article
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5 authors.
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Abstract
Firing rate variability at the single neuron level is characterized by long-memory processes and complex statistics over a wide range of time scales (from milliseconds up to several hours). Here, we focus on the contribution of non-stationary efficacy of the ensemble of synapses-activated in response to a given stimulus-on single neuron response variability. We present and validate a method tailored for controlled and specific long-term activation of a single cortical neuron in vitro via synaptic or antidromic stimulation, enabling a clear separation between two determinants of neuronal response variability: membrane excitability dynamics vs. synaptic dynamics. Applying this method we show that, within the range of physiological activation frequencies, the synaptic ensemble of a given neuron is a key contributor to the neuronal response variability, long-memory processes and complex statistics observed over extended time scales. Synaptic transmission dynamics impact on response variability in stimulation rates that are substantially lower compared to stimulation rates that drive excitability resources to fluctuate. Implications to network embedded neurons are discussed.
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