Evidence map›Paper›PMID 25071001›Full record

ArticleThe American journal of tropical medicine and hygiene2014

Treatment outcomes for patients with multidrug-resistant tuberculosis in post-earthquake Port-au-Prince, Haiti.

Macarthur Charles, Stalz Charles Vilbrun, Serena P Koenig, Lauren M Hashiguchi, Marie Marcelle Mabou, Oksana Ocheretina, Jean W Pape

Abstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Time to treatment for rifampicin-resistant tuberculosis: systematic review and meta-analysis.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2017
    Pooled it
  4. Pooled it
  5. Article
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  8. Review
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  10. Survival Status and Predictors of Mortality among Multidrug-Resistant Tuberculosis Patients in Saint Peter's Specialized Hospital, Addis Ababa, Ethiopia.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Macarthur CharlesLes Centres Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO), Port-au-Prince, Haiti; Division of Global Health Equity, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Masters of Science in Public Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Division of Infectious Diseases, Center for Global Health, Weill Cornell Medical College, New York, New York makchuk@gmail.com.
Stalz Charles VilbrunLes Centres Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO), Port-au-Prince, Haiti; Division of Global Health Equity, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Masters of Science in Public Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Division of Infectious Diseases, Center for Global Health, Weill Cornell Medical College, New York, New York.
Serena P KoenigLes Centres Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO), Port-au-Prince, Haiti; Division of Global Health Equity, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Masters of Science in Public Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Division of Infectious Diseases, Center for Global Health, Weill Cornell Medical College, New York, New York.
Lauren M HashiguchiLes Centres Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO), Port-au-Prince, Haiti; Division of Global Health Equity, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Masters of Science in Public Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Division of Infectious Diseases, Center for Global Health, Weill Cornell Medical College, New York, New York.
Marie Marcelle MabouLes Centres Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO), Port-au-Prince, Haiti; Division of Global Health Equity, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Masters of Science in Public Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Division of Infectious Diseases, Center for Global Health, Weill Cornell Medical College, New York, New York.
Oksana OcheretinaLes Centres Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO), Port-au-Prince, Haiti; Division of Global Health Equity, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Masters of Science in Public Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Division of Infectious Diseases, Center for Global Health, Weill Cornell Medical College, New York, New York.
Jean W PapeLes Centres Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO), Port-au-Prince, Haiti; Division of Global Health Equity, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Masters of Science in Public Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Division of Infectious Diseases, Center for Global Health, Weill Cornell Medical College, New York, New York.

Funding

GHESKIO HIV Clinical Trial UnitUM1AI069421 · NIAID · GHESKIO CENTER · PI JEAN WILLIAM PAPE · 2012 to 2026
$23.6M
GHESKIO HIV Clinical Trial UnitU01AI069421 · NIAID · GHESKIO CENTER · PI PAPE, JEAN WILLIAM · 2007 to 2011
$8.4M
Same-Day HIV Testing and Treatment Initiation to Improve Retention in CareR01AI104344 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI KOENIG, SERENA PATRICIA · 2013 to 2015
$1.9M
Monitoring Response to ARV Therapy and Development of HIV-1 Drug ResistanceK23AI073190 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHARLES, MACARTHUR · 2008 to 2012
$654k
NIAID NIH HHS K23 AI073190NIAID NIH HHS R01 AI104344NIAID NIH HHS R01AI104344NIAID NIH HHS UM1 AI069421PEPFAR
6 · The paper itself

Abstract

We report outcomes and 12-month survival for the first cohort of patients to undergo multidrug-resistant tuberculosis (MDR-TB) treatment after the earthquake in Haiti. From March 3, 2010 to March 28, 2013, 110 patients initiated treatment of laboratory-confirmed MDR-TB at the Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunistes (GHESKIO) Center in Port-au-Prince, Haiti. Twenty-seven patients (25%) were human immunodeficiency virus (HIV)-positive. As of October 31, 2013, 95 (86%) patients were either cured or alive on treatment, 4 (4%) patients defaulted, and 11 (10%) patients died. Culture conversion occurred by 30 days in 14 (13%) patients, 60 days in 49 (45%) patients, and 90 days in 81 (74%) patients. The probabilities of survival to 12 months were 96% (95% confidence interval [95% CI] = 89-99) and 85% (95% CI = 64-94) for HIV-negative and -positive patients, respectively. Despite adverse conditions, outcomes for patients with MDR-TB are highly encouraging. Major efforts are underway to scale up community directly observed therapy and expand care to other regions of Haiti.

Indexed as

HIV SeronegativityAdultAnti-HIV AgentsAntitubercular AgentsCohort StudiesDirectly Observed TherapyDisastersEarthquakesFemaleFollow-Up StudiesHaitiHIV SeropositivityHumansKaplan-Meier EstimateMaleSputumAnti-HIV AgentsAntitubercular Agents

Identifiers

PMID25071001
PMCPMC4183393

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.