ArticleThe Journal of cell biology2014
Radial intercalation is regulated by the Par complex and the microtubule-stabilizing protein CLAMP/Spef1.
Article in The Journal of cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 63 citations in OpenAlex.
- Reciprocal E-cadherin signaling aligns apical surfaces between neighboring epithelial tissues to complete the C. elegans digestive tract.Current biology : CB · 2026Article
- A protein complex in the extreme distal tip of vertebrate motile cilia controls their organization, length, and function.Nature communications · 2025Article
- Calcium transients regulate the apical emergence of basally located progenitors during Xenopus skin development.Nature communications · 2025Article
- A protein complex in the extreme distal tip of vertebrate motile cilia controls their organization, length, and function.bioRxiv : the preprint server for biology · 2025Article
- Apical size reduction by macropinocytosis alleviates tissue crowding.Nature communications · 2025Article
- Ccdc13 is essential for the assembly of ciliary central microtubules.National science review · 2025Article
- Article
- Multicellular rosettes link mesenchymal-epithelial transition to radial intercalation in the mouse axial mesoderm.Developmental cell · 2023Article
- Multiciliated cells use filopodia to probe tissue mechanics during epithelial integration in vivo.Nature communications · 2022Article
- Spef1/CLAMP binds microtubules and actin-based structures and regulates cell migration and epithelia cell polarity.Annals of the New York Academy of Sciences · 2022Review
- Won't You be My Neighbor: How Epithelial Cells Connect Together to Build Global Tissue Polarity.Frontiers in cell and developmental biology · 2022Review
- Tubulin acetylation promotes penetrative capacity of cells undergoing radial intercalation.Cell reports · 2021Article
- Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells.eLife · 2021Article
- A role for Cep70 in centriole amplification in multiciliated cells.Developmental biology · 2021Article
- Basal Body Protein TbSAF1 Is Required for Microtubule Quartet Anchorage to the Basal Bodies inmBio · 2020Article
- Centriole Number and the Accumulation of Microtubules Modulate the Timing of Apical Insertion during Radial Intercalation.Current biology : CB · 2020Article
- Endfoot regeneration restricts radial glial state and prevents translocation into the outer subventricular zone in early mammalian brain development.Nature cell biology · 2020Article
- Sperm Flagellar 1 Binds Actin in Intestinal Epithelial Cells and Contributes to Formation of Filopodia and Lamellipodia.Gastroenterology · 2019Article
- Developmentally regulated GTP-binding protein 1 modulates ciliogenesis via an interaction with Dishevelled.The Journal of cell biology · 2019Article
- Desmoplakin is required for epidermal integrity and morphogenesis in the Xenopus laevis embryo.Developmental biology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The directed movement of cells is critical for numerous developmental and disease processes. A developmentally reiterated form of migration is radial intercalation; the process by which cells move in a direction orthogonal to the plane of the tissue from an inner layer to an outer layer. We use the radial intercalation of cells into the skin of Xenopus laevis embryos as a model to study directed cell migration within an epithelial tissue. We identify a novel function for both the microtubule-binding protein CLAMP and members of the microtubule-regulating Par complex during intercalation. Specifically, we show that Par3 and aPKC promote the apical positioning of centrioles, whereas CLAMP stabilizes microtubules along the axis of migration. We propose a model in which the Par complex defines the orientation of apical migration during intercalation and in which subcellular localization of CLAMP promotes the establishment of an axis of microtubule stability required for the active migration of cells into the outer epithelium.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.