SynthesisThe clinical respiratory journal2016
Dyspnea as an independent predictor of mortality.
Synthesis in The clinical respiratory journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed.
- Dyspnea is severe and associated with a higher intubation rate in de novo acute hypoxemic respiratory failure.Critical care (London, England) · 2024Trial
- Breathlessness and incidence of COPD, cardiac events and all-cause mortality: A 44-year follow-up from middle age throughout life.PloS one · 2019Trial
- Objective dyspnea measurement in real time using a forehead wearable and artificial intelligence.NPJ primary care respiratory medicine · 2026Article
- Ethnic differences in healthcare utilisation and diagnosis after first presentation with breathlessness: a retrospective cohort study using UK primary care records.NPJ primary care respiratory medicine · 2026Article
- Global disparities in chronic dyspnoea prevalence in population-based studies: a comprehensive literature review.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- "Breathlessness stops me doing everything": exploring the impact of chronic breathlessness due to advanced respiratory disease and exacerbating factors - a qualitative study.ERJ open research · 2026Article
- Patient-reported dyspnoea predicts six-fold increased hospital mortality.ERJ open research · 2026Article
- Interstitial lung disease in systemic sclerosis-a retrospective cross-sectional study in Taiwan.Clinical rheumatology · 2026Article
- Dyspnea as a marker of prognosis in immunocompromised patients with acute respiratory failure.Annals of intensive care · 2026Article
- Galectin-3 Is Independently Associated With Short-Term Mortality and Identifies Low-Risk Patients With Acute Dyspnea in the Emergency Department: A Retrospective Cohort Study.Biomarker insights · 2026Article
- How do structural inequalities influence COVID-19 hospital mortality among traditional peoples and communities? A cross-sectional study in São Paulo, Brazil, 2021-2023.BMJ public health · 2026Article
- Greater ambient air pollution exposure is associated with worse respiratory symptoms in men and women with HIV and chronic lung disease: a cohort study.Respiratory research · 2025Article
- Changes of respiratory microbiota associated with prognosis in pulmonary infection patients with invasive mechanical ventilation-supported respiratory failure.Annals of medicine · 2025Article
- Intense optimization of oral therapy rapidly restores respiratory function in worsening heart failure patients.ESC heart failure · 2025Observational
- Subjective geriatric complaints as predictors of disability and mortality in community-dwelling older adults: a 5-year cohort study.Age and ageing · 2025Article
- Self-reported dyspnea and interest in a respiratory muscle training program among callers to the New York State Quitline.Tobacco induced diseases · 2025Article
- Associations between Chest Pain, Diagnosis, and Clinical Outcome in Patients Hospitalized with Acute Dyspnea: Data from the ACE 2 Study.Cardiology · 2025Article
- Striving for moments of easier breathing despite being trapped in breathlessness: meanings of feeling well for women with chronic obstructive pulmonary disease stage III or IV.International journal of qualitative studies on health and well-being · 2023Article
- Hybrid delivery of cluster-set resistance training for individuals previously treated for lung cancer: the results of a single-arm feasibility trial.Pilot and feasibility studies · 2023Article
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Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
BACKGROUND AND
aimDyspnea is a common and easily elicited presenting complaint in patients seen by physicians who evaluate and take care of chronic respiratory disorders. Although dyspnea is subjective and tends to increase with age or reduced lung function, it appears to be reproducible as a symptom and often signifies serious underlying disease.
methodsSystematic review of longitudinal studies with dyspnea as the exposure and mortality as the outcome; age, smoking and lung function had to be controlled for to be included in the review. In addition, a minimum sample size at baseline of 500 subjects was required for each study.
resultsFrom over 3000 potential references, 10 longitudinal studies met all criteria and were included. All 10 studies suggested that dyspnea was an independent predictor of mortality with point estimates by odds ratio, rate ratio or hazard ratios ranging from 1.3 up to 2.9-fold greater than baseline. All 10 studies had actual or implied 95% confidence interval bands greater than the null value of one.
conclusionDyspnea, a symptom, predicts mortality and is a proxy for underlying diseases, most often of heart and lung. Therefore, chronic dyspnea needs to be evaluated as to etiology to allow for treatment to minimize morbidity and mortality when possible.
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