ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015
Fibroblasts From Longer-Lived Species of Primates, Rodents, Bats, Carnivores, and Birds Resist Protein Damage.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Unlocking longevity through the comparative biology of aging.Nature aging · 2025Review
- Bats as instructive animal models for studying longevity and aging.Annals of the New York Academy of Sciences · 2024Review
- Sex as a biological variable in ageing: insights and perspectives on the molecular and cellular hallmarks.Open biology · 2024Review
- Primary Cell Culture as a Model System for Evolutionary Molecular Physiology.International journal of molecular sciences · 2024Review
- Distinct longevity mechanisms across and within species and their association with aging.Cell · 2023Article
- A new approach method for characterizing inter-species toxicodynamic variability.Journal of toxicology and environmental health. Part A · 2021Article
- Plasma methionine metabolic profile is associated with longevity in mammals.Communications biology · 2021Article
- New Perspectives on Avian Models for Studies of Basic Aging Processes.Biomedicines · 2021Review
- Growth hormone and aging.Reviews in endocrine & metabolic disorders · 2021Review
- High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance.Science advances · 2020Article
- Aggresome-Like Formation Promotes Resistance to Proteotoxicity in Cells from Long-Lived Species.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Cellular parabiosis and the latency of age-related diseases.Open biology · 2019Review
- Article
- Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease.Biochimica et biophysica acta. Molecular basis of disease · 2019Review
- Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells.Aging cell · 2019Review
- To adapt or not to adapt: Consequences of declining Adaptive Homeostasis and Proteostasis with age.Mechanisms of ageing and development · 2019Review
- Article
- Comparative metabolomics of aging in a long-lived bat: Insights into the physiology of extreme longevity.PloS one · 2018Article
- Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses.PLoS biology · 2017Article
- Mitochondrial thioredoxin reductase 2 is elevated in long-lived primate as well as rodent species and extends fly mean lifespan.Aging cell · 2017Article
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Authors and funding
5 authors.
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Abstract
Species differ greatly in their rates of aging. Among mammalian species life span ranges from 2 to over 60 years. Here, we test the hypothesis that skin-derived fibroblasts from long-lived species of animals differ from those of short-lived animals in their defenses against protein damage. In parallel studies of rodents, nonhuman primates, birds, and species from the Laurasiatheria superorder (bats, carnivores, shrews, and ungulates), we find associations between species longevity and resistance of proteins to oxidative stress after exposure to H(2)O(2) or paraquat. In addition, baseline levels of protein carbonyl appear to be higher in cells from shorter-lived mammals compared with longer-lived mammals. Thus, resistance to protein oxidation is associated with species maximal life span in independent clades of mammals, suggesting that this cellular property may be required for evolution of longevity. Evaluation of the properties of primary fibroblast cell lines can provide insights into the factors that regulate the pace of aging across species of mammals.
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