Trial reportBMJ (Clinical research ed.)1989
Effect of captopril on blood pressure and kidney function in normotensive insulin dependent diabetics with nephropathy.
Trial report in BMJ (Clinical research ed.), 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 175 citations in OpenAlex.
- Angiotensin-converting-enzyme inhibitors and angiotensin receptor blockers for preventing the progression of diabetic kidney disease.The Cochrane database of systematic reviews · 2024Pooled it
- Effects of renin-angiotensin system blockers on renal and cardiovascular outcomes in patients with diabetic nephropathy: a meta-analysis of randomized controlled trials.Journal of endocrinological investigation · 2020Pooled it
- A cost-effectiveness analysis of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in diabetic nephropathy.Journal of clinical hypertension (Greenwich, Conn.) · 2007Pooled it
- Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists for preventing the progression of diabetic kidney disease.The Cochrane database of systematic reviews · 2006Pooled it
- Effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on cardiovascular events in patients with diabetes and overt nephropathy: a meta-analysis of randomised controlled trials.Journal of the renin-angiotensin-aldosterone system : JRAASPooled it
- Trial
- Efficacy and Safety of Niaoduqing Particles for Delaying Moderate-to-severe Renal Dysfunction: A Randomized, Double-blind, Placebo-controlled, Multicenter Clinical Study.Chinese medical journal · 2017Trial
- Captopril reduces the risk of nephropathy in IDDM patients with microalbuminuria. The Microalbuminuria Captopril Study Group.Diabetologia · 1996Trial
- Captopril and atenolol are equally effective in retarding progression of diabetic nephropathy. Results of a 2-year prospective, randomized study.Diabetologia · 1994Trial
- Renal protective effect of enalapril in diabetic nephropathy.BMJ (Clinical research ed.) · 1992Trial
- UK Prospective Diabetes Study (UKPDS). VIII. Study design, progress and performance.Diabetologia · 1991Trial
- Enalapril reduces microalbuminuria in young normotensive type 1 (insulin-dependent) diabetic patients irrespective of its hypotensive effect.Diabetologia · 1990Trial
- Protective effect of captopril on the blood-retina barrier in normotensive insulin-dependent diabetic patients with nephropathy and background retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 1990Trial
- Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis.Nature medicine · 2012Article
- What is the optimal strategy to intensify blood pressure control and prevent progression of renal failure?Current hypertension reports · 2001Review
- Review
- Development and progression of microalbuminuria in a clinic sample of patients with insulin dependent diabetes mellitus.Archives of disease in childhood · 1998Article
- Diabetic nephropathy. Its relationship to hypertension and means of pharmacological intervention.Drugs · 1997Review
- Diabetic vascular injury and ACE. Potential for pharmacological prevention of complications of later life.Drugs & aging · 1996Review
- Microalbuminuria and nephropathy in insulin dependent diabetes mellitus.Archives of disease in childhood · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess whether inhibition of angiotensin converting enzyme protects kidney function in diabetic nephropathy.
designOpen, randomised follow up study of normotensive insulin dependent diabetics with nephropathy either treated or not with captopril for one year.
settingOutpatient diabetic clinic in a tertiary referral centre. PATIENTS: 32 Normotensive patients with insulin dependent diabetes complicated by nephropathy who were randomised either to the treatment group (n = 15) or to the control group (n = 17).
interventionsThe treatment group was given captopril (25-100 mg/day) for 12 months, the average dose during the second six months of the study being 40 mg daily. Controls were not treated.
main outcome measuresAlbuminuria, arterial blood pressure, and the glomerular filtration rate.
resultsMean arterial blood pressure fell by 3 (SE 2) mm Hg in the captopril treated group and rose by 6 (1) mm Hg in the controls. In addition, albuminuria declined by 11% in the captopril treated group and rose by 55% in the controls, fractional albumin clearance fell by 17% in the captopril treated group and increased by 66% in the controls, and the glomerular filtration rate declined by 3.1 (2.8)ml/min/1.73 m2 with captopril and by 6.4 (3.1) ml/min/1.73 m2 in the controls.
conclusionInhibition of angiotensin converting enzyme arrests the progressive rise in albuminuria in normotensive insulin dependent diabetics with nephropathy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.