ArticleGenome biology and evolution2014
Long-term asymmetrical acceleration of protein evolution after gene duplication.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Quantifying the Influence of Genetic Context on Duplicated Mammalian Genes.Molecular biology and evolution · 2026Article
- Article
- Unveiling the functional fate of duplicated genes through expression profiling and structural analysis.Genome research · 2025Article
- Quantifying the influence of genetic context on duplicated mammalian genes.bioRxiv : the preprint server for biology · 2025Article
- A lateral flow immunoassay-based survey reveals a low-frequency truncated Solenopsis invicta venom 2-like protein and unique Solenopsis invicta venom 2 protein genotypes inFrontiers in insect science · 2025Article
- Article
- Genome-Wide Analysis of the DC1 Domain Protein Gene Family in Tomatoes under Abiotic Stress.International journal of molecular sciences · 2023Article
- Evolutionary Trajectories of New Duplicated and Putative De Novo Genes.Molecular biology and evolution · 2023Article
- Extended disordered regions of ribosome-associated NAC proteins paralogs belong only to the germline in Drosophila melanogaster.Scientific reports · 2022Article
- Special Care Is Needed in Applying Phylogenetic Comparative Methods to Gene Trees with Speciation and Duplication Nodes.Molecular biology and evolution · 2021Article
- Selection following Gene Duplication Shapes Recent Genome Evolution in the Pea Aphid Acyrthosiphon pisum.Molecular biology and evolution · 2020Article
- Duplication and functional divergence of a calcium sensor in the Brassicaceae.Journal of experimental botany · 2020Article
- Neofunctionalization of Mitochondrial Proteins and Incorporation into Signaling Networks in Plants.Molecular biology and evolution · 2019Article
- New Genes and Functional Innovation in Mammals.Genome biology and evolution · 2017Article
- Resurrecting ancestral structural dynamics of an antiviral immune receptor: adaptive binding pocket reorganization repeatedly shifts RNA preference.BMC evolutionary biology · 2016Article
- Transcriptional Interference Promotes Rapid Expression Divergence of Drosophila Nested Genes.Genome biology and evolution · 2016Article
- Key Role of Amino Acid Repeat Expansions in the Functional Diversification of Duplicated Transcription Factors.Molecular biology and evolution · 2015Article
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2 authors.
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Abstract
Rapid divergence of gene copies after duplication is thought to determine the fate of the copies and evolution of novel protein functions. However, data on how long the gene copies continue to experience an elevated rate of evolution remain scarce. Standard theory of gene duplications based on some level of genetic redundancy of gene copies predicts that the period of accelerated evolution must end relatively quickly. Using a maximum-likelihood approach we estimate preduplication, initial postduplication, and recent postduplication rates of evolution that occurred in the mammalian lineage. We find that both gene copies experience a similar in magnitude acceleration in their rate of evolution. The copy located in the original genomic position typically returns to the preduplication rates of evolution in a short period of time. The burst of faster evolution of the copy that is located in a new genomic position typically lasts longer. Furthermore, the fast-evolving copies on average continue to evolve faster than the preduplication rates far longer than predicted by standard theory of gene duplications. We hypothesize that the prolonged elevated rates of evolution are determined by functional properties that were acquired during, or soon after, the gene duplication event.
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