ArticleGenome biology and evolution2014
Genome evolution and plasticity of Serratia marcescens, an important multidrug-resistant nosocomial pathogen.
Article in Genome biology and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers.
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Who cites it
111 citing papers in PubMed, 189 citations in OpenAlex.
- Serratia Bacteraemia in the North Denmark Region: A Population-Based Study (2010-2024).APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026Article
- The current discordance on Serratia spp. taxonomical diagnosis using proteomics or genomic tools.BMC microbiology · 2026Article
- Diagnostic challenges and Gram-negative pathogen dominance in early- and late-onset neonatal infection in Manila, Philippines.Nature communications · 2026Article
- From Environmental Organism to Nosocomial Threat:Antibiotics (Basel, Switzerland) · 2026Review
- Prevalence and activity of class II microcins inApplied and environmental microbiology · 2026Article
- Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2026Review
- Metagenomic analysis of UK retail foods finds limited evidence for associations between food production method and antimicrobial resistance gene burden.Microbial genomics · 2026Article
- Ecological dynamics of three persistent opportunistic pathogens in hospital sinks and their potential antagonistic bacteria.mSystems · 2026Article
- Genomic Insights Into Multidrug-Resistant FoodborneInternational journal of food science · 2026Article
- Molecular Epidemiology of Carbapenem-ResistantInfection and drug resistance · 2026Article
- A widely-occurring family of pore-forming effectors broadens the impact of the Serratia Type VI secretion system.The EMBO journal · 2025Article
- Prodigiosin as an Algicidal Agent: Inhibition of Pigment Accumulation and Photosynthetic Efficiency of Cyanobacteria Involved in Algal Blooms.Microorganisms · 2025Article
- Genomic and phenotypic insights into Serratia interaction with plants from an ecological perspective.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Competitive behaviors in Serratia marcescens are coordinately regulated by a lifestyle switch frequently inactivated in the clinical environment.Cell host & microbe · 2025Article
- Genomes of novelMicrobiology resource announcements · 2025Article
- Molecular epidemiology of a carbapenem-resistantFrontiers in microbiology · 2025Article
- Genome-resolved analysis of Serratia marcescens strain SMTT infers niche specialization as a hydrocarbon-degrader.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Impact of the Stress Response on Quaternary Ammonium Compound Disinfectant Susceptibility inMicroorganisms · 2024Article
- Differential Expression Analysis Reveals Possible New Quaternary Ammonium Compound Resistance Gene in Highly ResistantMicroorganisms · 2024Article
- Geographical, Seasonal, and Growth-Related Dynamics of Gut Microbiota in a Grapevine Pest, Apolygus spinolae (Heteroptera: Miridae).Microbial ecology · 2024Article
51 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors at 9 institutions in 3 countries.
Funding
Abstract
Serratia marcescens is an important nosocomial pathogen that can cause an array of infections, most notably of the urinary tract and bloodstream. Naturally, it is found in many environmental niches, and is capable of infecting plants and animals. The emergence and spread of multidrug-resistant strains producing extended-spectrum or metallo beta-lactamases now pose a threat to public health worldwide. Here we report the complete genome sequences of two carefully selected S. marcescens strains, a multidrug-resistant clinical isolate (strain SM39) and an insect isolate (strain Db11). Our comparative analyses reveal the core genome of S. marcescens and define the potential metabolic capacity, virulence, and multidrug resistance of this species. We show a remarkable intraspecies genetic diversity, both at the sequence level and with regards genome flexibility, which may reflect the diversity of niches inhabited by members of this species. A broader analysis with other Serratia species identifies a set of approximately 3,000 genes that characterize the genus. Within this apparent genetic diversity, we identified many genes implicated in the high virulence potential and antibiotic resistance of SM39, including the metallo beta-lactamase and multiple other drug resistance determinants carried on plasmid pSMC1. We further show that pSMC1 is most closely related to plasmids circulating in Pseudomonas species. Our data will provide a valuable basis for future studies on S. marcescens and new insights into the genetic mechanisms that underlie the emergence of pathogens highly resistant to multiple antimicrobial agents.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.