ArticleThe Journal of general physiology2014
F-/Cl- selectivity in CLCF-type F-/H+ antiporters.
Article in The Journal of general physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 55 citations in OpenAlex.
- Adaptive evolution ofJournal of bacteriology · 2026Article
- The molecular mechanism of fluoride export by the eukaryotic fluoride channel FEX.Nature communications · 2025Article
- The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis.Nature communications · 2024Review
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- Toward the development of a molecular toolkit for the microbial remediation of per-and polyfluoroalkyl substances.Applied and environmental microbiology · 2024Review
- Fluoride Ion Binding and Translocation in the CLCThe journal of physical chemistry. B · 2024Article
- Fluoride export is required for competitive fitness of pathogenic microorganisms in dental biofilm models.bioRxiv : the preprint server for biology · 2024Article
- Lanthanum-fluoride electrode-based methods to monitor fluoride transport in cells and reconstituted lipid vesicles.Methods in enzymology · 2024Article
- Fluoride Transport and Inhibition Across CLC Transporters.Handbook of experimental pharmacology · 2024Article
- The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins.eLife · 2023Article
- The Contribution of Hydrophobic Interactions to Conformational Changes of Inward/Outward Transmembrane Transport Proteins.Membranes · 2022Article
- Article
- Membrane Exporters of Fluoride Ion.Annual review of biochemistry · 2021Review
- The application of Poisson distribution statistics in ion channel reconstitution to determine oligomeric architecture.Methods in enzymology · 2021Article
- Genome-wide identification and expression analysis of the CLC superfamily genes in tea plants (Camellia sinensis).Functional & integrative genomics · 2020Article
- Census of halide-binding sites in protein structures.Bioinformatics (Oxford, England) · 2020Article
- An Interfacial Sodium Ion is an Essential Structural Feature of Fluc Family Fluoride Channels.Journal of molecular biology · 2020Article
- Transmembrane Fluoride Transport by a Cyclic Azapeptide With Two β-Turns.Frontiers in chemistry · 2020Article
- Heavy Pnictogenium Cations as Transmembrane Anion Transporters in Vesicles and Erythrocytes.Chem · 2019Article
- Fast and selective fluoride ion conduction in sub-1-nanometer metal-organic framework channels.Nature communications · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Many bacterial species protect themselves against environmental F(-) toxicity by exporting this anion from the cytoplasm via CLC(F) F(-)/H(+) antiporters, a subclass of CLC superfamily anion transporters. Strong F(-) over Cl(-) selectivity is biologically essential for these membrane proteins because Cl(-) is orders of magnitude more abundant in the biosphere than F(-). Sequence comparisons reveal differences between CLC(F)s and canonical Cl(-)-transporting CLCs within regions that, in the canonical CLCs, coordinate Cl(-) ion and govern anion transport. A phylogenetic split within the CLC(F) clade, manifested in sequence divergence in the vicinity of this ion-binding center, raises the possibility that these two CLC(F) subclades might exhibit differences in anion selectivity. Several CLC(F) homologues from each subclade were examined for F(-)/Cl(-) selectivity of anion transport and equilibrium binding. Differences in both of these anion-selectivity metrics correlate with sequence divergence among CLC(F)s. Chimeric constructs identify two residues in this region that largely account for the subclade differences in selectivity. In addition, these experiments serendipitously uncovered an unusually steep, Cl(-)-specific voltage dependence of transport that greatly enhances F(-) selectivity at low voltage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.