Evidence map›Paper›PMID 25070097›Full record

ArticleAntimicrobial agents and chemotherapy2014

Population pharmacokinetics of abacavir in pregnant women.

Floris Fauchet, Jean-Marc Treluyer, Laure-Helene Préta, Elodie Valade, Emmanuelle Pannier, Saik Urien, Déborah Hirt

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Floris FauchetEA 08 Université Paris Descartes, Sorbonne Paris Cité, Paris, France Unité de Recherche Clinique, AP-HP, Hôpital Tarnier, Paris, France florisfauchet@gmail.com.
Jean-Marc TreluyerEA 08 Université Paris Descartes, Sorbonne Paris Cité, Paris, France Unité de Recherche Clinique, AP-HP, Hôpital Tarnier, Paris, France Service de Pharmacologie Clinique, AP-HP, Groupe Hospitalier Paris Centre, Paris, France CIC-0901 Inserm, Cochin-Necker, Paris, France.
Laure-Helene PrétaEA 08 Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Elodie ValadeEA 08 Université Paris Descartes, Sorbonne Paris Cité, Paris, France Unité de Recherche Clinique, AP-HP, Hôpital Tarnier, Paris, France.
Emmanuelle PannierService de Gynécologie-Obstétrique, Maternité Port Royal, Groupe Hospitalier Paris Centre, Paris, France.
Saik UrienEA 08 Université Paris Descartes, Sorbonne Paris Cité, Paris, France Unité de Recherche Clinique, AP-HP, Hôpital Tarnier, Paris, France CIC-0901 Inserm, Cochin-Necker, Paris, France.
Déborah HirtEA 08 Université Paris Descartes, Sorbonne Paris Cité, Paris, France Unité de Recherche Clinique, AP-HP, Hôpital Tarnier, Paris, France Service de Pharmacologie Clinique, AP-HP, Groupe Hospitalier Paris Centre, Paris, France CIC-0901 Inserm, Cochin-Necker, Paris, France.
Sorbonne Paris Cité · FRDélégation Paris 5 · FRInserm · FRMaternité Port Royal · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For the first time, a population approach was used to describe abacavir (ABC) pharmacokinetics in HIV-infected pregnant and nonpregnant women. A total of 266 samples from 150 women were obtained. No covariate effect (from age, body weight, pregnancy, or gestational age) on ABC pharmacokinetics was found. Thus, it seems unnecessary to adapt the ABC dosing regimen during pregnancy.

Indexed as

AbacavirAnti-HIV AgentsDideoxynucleosidesFemaleHIV InfectionsHumansPregnancyAbacavirAnti-HIV AgentsDideoxynucleosides

Identifiers

PMID25070097
PMCPMC4187964
OpenAlexW2010938065

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.