ArticleAntimicrobial agents and chemotherapy2014
Whole-genome assembly of Klebsiella pneumoniae coproducing NDM-1 and OXA-232 carbapenemases using single-molecule, real-time sequencing.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Molecular epidemiology of carbapenemase-producing Klebsiella pneumoniae in Gauteng South Africa.Scientific reports · 2024Article
- Genomic characterization of carbapenem and colistin-resistantFrontiers in veterinary science · 2024Article
- Prevalence and Molecular Characteristics of 16S rRNA Methylase Genes in Clinical Isolates of Carbapenem-Resistant Enterobacterales.Infection and drug resistance · 2024Article
- Two colistin resistance-producingFrontiers in microbiology · 2024Article
- Long-read sequencing reveals genomic diversity and associated plasmid movement of carbapenemase-producing bacteria in a UK hospital over 6 years.Microbial genomics · 2023Article
- Polyclonal Dissemination of OXA-232 Carbapenemase-Producing Klebsiella pneumoniae, France, 2013-2021.Emerging infectious diseases · 2022Article
- ISMicrobial genomics · 2022Article
- Nationwide surveillance in Thailand revealed genotype-dependent dissemination of carbapenem-resistantMicrobial genomics · 2022Article
- Clinical carbapenem-resistantFrontiers in cellular and infection microbiology · 2022Article
- Enzyme Inhibitors: The Best Strategy to Tackle Superbug NDM-1 and Its Variants.International journal of molecular sciences · 2021Review
- Sequence Analyses and Phenotypic Characterization Revealed Multidrug Resistant Gene Insertions in the Genomic Region Encompassing Phase 2 Flagellin EncodingFrontiers in microbiology · 2021Article
- Coinfections of Two Strains of NDM-1- and OXA-232-Coproducing Klebsiella pneumoniae in a Kidney Transplant Patient.Antimicrobial agents and chemotherapy · 2020Article
- Co-introduction of plasmids harbouring the carbapenemase genes, blaJournal of biomedical science · 2020Article
- Structural Genomics ofInfection and drug resistance · 2020Article
- SmallFrontiers in microbiology · 2019Article
- Genomic Characterization of Carbapenemase-Producing Klebsiella pneumoniae with Chromosomally CarriedAntimicrobial agents and chemotherapy · 2018Article
- Prevalence of Integrons and Insertion Sequences in ESBL-ProducingInternational journal of environmental research and public health · 2018Article
- Comparison of virulence between matt and mucoid colonies of Klebsiella pneumoniae coproducing NDM-1 and OXA-232 isolated from a single patient.Journal of microbiology (Seoul, Korea) · 2018Article
- Present and Future Surveillance of Antimicrobial Resistance in Animals: Principles and Practices.Microbiology spectrum · 2018Review
- Spread of Plasmid-Encoded NDM-1 and GES-5 Carbapenemases among Extensively Drug-Resistant and Pandrug-Resistant Clinical Enterobacteriaceae in Durban, South Africa.Antimicrobial agents and chemotherapy · 2018Article
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Authors and funding
7 authors.
Funding
Abstract
The whole-genome sequence of a carbapenem-resistant Klebsiella pneumoniae strain, PittNDM01, which coproduces NDM-1 and OXA-232 carbapenemases, was determined in this study. The use of single-molecule, real-time (SMRT) sequencing provided a closed genome in a single sequencing run. K. pneumoniae PittNDM01 has a single chromosome of 5,348,284 bp and four plasmids: pPKPN1 (283,371 bp), pPKPN2 (103,694 bp), pPKPN3 (70,814 bp), and pPKPN4 (6,141 bp). The contents of the chromosome were similar to that of the K. pneumoniae reference genome strain MGH 78578, with the exception of a large inversion spanning 23.3% of the chromosome. In contrast, three of the four plasmids are unique. The plasmid pPKPN1, an IncHI1B-like plasmid, carries the blaNDM-1, armA, and qnrB1 genes, along with tellurium and mercury resistance operons. blaNDM-1 is carried on a unique structure in which Tn125 is further bracketed by IS26 downstream of a class 1 integron. The IncFIA-like plasmid pPKPN3 also carries an array of resistance elements, including blaCTX-M-15 and a mercury resistance operon. The ColE-type plasmid pPKPN4 carrying blaOXA-232 is identical to a plasmid previously reported from France. SMRT sequencing was useful in resolving the complex bacterial genomic structures in the de novo assemblies.
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