ArticleNMR in biomedicine2014
Field dependence study of in vivo brain (31) P MRS up to 16.4 T.
Article in NMR in biomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
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- In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences.Proceedings of the National Academy of Sciences of the United States of America · 2015Trial
- ATP bioenergetics and fatigue in young adults with and without major depression.Translational psychiatry · 2026Article
- High-Resolution Brain Metabolic Imaging at Ultrahigh Field Using Extended Spatiospectral Encoding and Subspace Modeling.IEEE transactions on bio-medical engineering · 2025Article
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- Simultaneous assessment of cerebral glucose and oxygen metabolism and perfusion in rats using interleaved deuterium (NMR in biomedicine · 2025Article
- A Quantitative Comparison ofSensors (Basel, Switzerland) · 2024Article
- Mapping intracellular NAD content in entire human brain using phosphorus-31 MR spectroscopic imaging at 7 Tesla.Frontiers in neuroscience · 2024Article
- In vivo spectral editing of phosphorylethanolamine.Magnetic resonance in medicine · 2022Article
- 3DNMR in biomedicine · 2021Article
- Utilizing Dynamic Phosphorous-31 Magnetic Resonance Spectroscopy for the Early Detection of Acute Compartment Syndrome: A Pilot Study on Rats.Diagnostics (Basel, Switzerland) · 2021Article
- Quantitative Assessment of Occipital Metabolic and Energetic Changes in Parkinson's Patients, Using In VivoMetabolites · 2021Article
- Cerebral phosphoester signals measured by 31P magnetic resonance spectroscopy at 3 and 7 Tesla.PloS one · 2021Article
- Tunable Ultrahigh Dielectric Constant (tuHDC) Ceramic Technique to Largely Improve RF Coil Efficiency and MR Imaging Performance.IEEE transactions on medical imaging · 2020Article
- Magnetic resonance spectroscopy in the rodent brain: Experts' consensus recommendations.NMR in biomedicine · 2020Article
- On the magnetic field dependence of deuterium metabolic imaging.NMR in biomedicine · 2020Article
- Phosphocreatine Levels in the Left Thalamus Decline during Wakefulness and Increase after a Nap.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Quantitative imaging of brain energy metabolisms and neuroenergetics using in vivo X-nuclearJournal of magnetic resonance (San Diego, Calif. : 1997) · 2018Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In vivo (31) P MRS provides a unique tool for studying bioenergetics of living organs. Although its utility has been limited by the relatively low (31) P NMR sensitivity, increasing magnetic field strength (B0 ) could significantly improve the quality and reliability of the (31) P MR spectra for biomedical research. To quantitatively understand the field dependence of in vivo (31) P MRS for brain applications, (31) P NMR sensitivity of phosphocreatine (PCr) in rat brains was measured and compared at 9.4 T and 16.4 T. Additionally, the linewidths and T1 relaxation times of PCr and adenosine triphosphate (ATP) resonances obtained from human and animal brains over a wide B0 range from 4 T, 7 T, and 9.4 T to 16.4 T were examined and their field dependences were quantified. The results indicate an approximate 1.74-fold (31) P signal-to-noise ratio (SNR) gain for PCr at 16.4 T compared with 9.4 T. An approximate power 1.4 dependence of (31) P SNR on B0 was concluded. Substantial improvements in spectral resolution and significantly shortened T1 values of brain PCr and ATP were observed at high/ultrahigh fields, contributing to an additional sensitivity gain and spectral improvement. In summary, the overall findings from this study suggest that in vivo (31) P MRS should greatly benefit from high/ultrahigh fields for noninvasive assessment of altered bioenergetics and metabolic processes associated with brain function and neurological diseases.
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