Surgery. NSAIDs and risk of anastomotic leaks after colorectal surgery.

Julie Ann M Van Koughnett, Steven D Wexner

Abstract readComment

In one paragraph

Article in Nature reviews. Gastroenterology & hepatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

Impact of gut microbiota on colorectal anastomotic healing (Review).Molecular and clinical oncology · 2025
Review
Postoperative Complications After Colorectal Surgery: Where Are We in the Era of Enhanced Recovery?Current gastroenterology reports · 2020
Review
Enhanced recovery after surgery: implementing a new standard of surgical care.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2019
Review
Experimental study of diclofenac and its biliary metabolites on anastomotic healing.BJS open · 2018
Article
Effect of Perioperative Dexamethasone and Different NSAIDs on Anastomotic Leak Risk: A Propensity Score Analysis.World journal of surgery · 2016
Article
Microbial Glucuronidase Inhibition Reduces Severity of Diclofenac-Induced Anastomotic Leak in Rats.Surgical infections
Article

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Julie Ann M Van KoughnettDivision of General Surgery, Department of Surgery, University Hospital, Western University, 339 Windermere Road, Room C8-128, London, Ontario N6A 5A5, Canada.

Steven D WexnerDepartment of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic Florida, 2950 Cleveland Clinic Boulevard, Weston, FL 33331, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NSAIDs provide improved pain control and reduce the use of opioids--both important components of enhanced recovery programs after colorectal surgery. However, the possible association between NSAID use and anastomotic leaks is greatly debated. Anastomotic leak remains an important concern due to the substantial associated morbidity.

Indexed as

Elective Surgical ProceduresAnastomotic LeakAnti-Inflammatory Agents, Non-SteroidalColonFemaleHumansIleumKetorolacMalePerioperative CareRectumAnti-Inflammatory Agents, Non-SteroidalKetorolac

Identifiers

PMID25069542

DOI10.1038/nrgastro.2014.130

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.