ArticleJournal of affective disorders2014
Differential abnormalities of functional connectivity of the amygdala and hippocampus in unipolar and bipolar affective disorders.
Article in Journal of affective disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Cell-type-specific genetic architecture reveals neuronal and immune contributions to neuropsychiatric disorders.Molecular psychiatry · 2026Article
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- Stress induces insertion of calcium-permeable AMPA receptors in the OFC-BLA synapse and modulates emotional behaviours in mice.Translational psychiatry · 2020Article
- Amygdala Circuitry During Neurofeedback Training and Symptoms' Change in Adolescents With Varying Depression.Frontiers in behavioral neuroscience · 2020Article
- Neurofeedback and neuroplasticity of visual self-processing in depressed and healthy adolescents: A preliminary study.Developmental cognitive neuroscience · 2019Article
- Procedural memory consolidation after a night of sleep in bipolar disorder with psychotic features.Schizophrenia research · 2019Article
- Regional Cerebral Blood Flow inFrontiers in psychiatry · 2018Article
- Citalopram Ameliorates Synaptic Plasticity Deficits in Different Cognition-Associated Brain Regions Induced by Social Isolation in Middle-Aged Rats.Molecular neurobiology · 2017Article
- Reward Processing in Unipolar and Bipolar Depression: A Functional MRI Study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Role of perinatal long-chain omega-3 fatty acids in cortical circuit maturation: Mechanisms and implications for psychopathology.World journal of psychiatry · 2015Review
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8 authors.
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Abstract
objectiveThe amygdala and hippocampus - two structures intimately associated with mood and cognition - have been reported to exhibit altered neural activity or volume in affective disorders. We hypothesized the amygdala and hippocampus would show altered and differential patterns of connectivity in patients with bipolar (BPs) and unipolar (UPs) disorder compared to healthy volunteers.
methodThirty BPs, 34 UPs, and 66 healthy volunteers were imaged using F-18-fluorodeoxyglucose and positron emission tomography while performing an auditory continuous performance task (CPT). Normalized mean activity of the amygdala and hippocampus was correlated with the rest of the brain.
resultsIn BPs, the amygdalae displayed exaggerated positive metabolic correlations with prefrontal and ventral striatal areas, while the hippocampus showed a paucity of normal inter-relations compared to controls. In contrast, in UPs the amygdala was significantly negatively correlated with prefrontal and anterior cingulate cortex, while the hippocampus was significantly more positively correlated to these same prefrontal areas.
conclusionsDuring a simple cognitive task, the functional connectivity of the amygdala and hippocampus, regions usually associated with emotion and memory regulation, was substantially different in affective illness compared to healthy controls whether or not there were baseline abnormalities in these areas. These striking differences in functional connectivity of amygdala and hippocampus should be further explored in ill and well states and using more specific emotion and cognitive evocative tasks.
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