ArticleMolecules (Basel, Switzerland)2014
Dereplication guided discovery of secondary metabolites of mixed biosynthetic origin from Aspergillus aculeatus.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Diversity of specialized metabolites in Phaeoacremonium species revealed by untargeted metabolomics and bioactivity assays.Scientific reports · 2026Article
- Antimicrobial potential of actinomycetes from high altitude Nepalese soils.Scientific reports · 2025Article
- Profiling of bioactive secondary metabolites from Aspergillus niger against a guava wilt pathogen, Fusarium oxysporum f. sp. psidii.Archives of microbiology · 2024Article
- Accessing the synthesis of natural products and their analogues enabled by the Barbier reaction: a review.RSC advances · 2024Review
- Fungal BGCs for Production of Secondary Metabolites: Main Types, Central Roles in Strain Improvement, and Regulation According to the Piano Principle.International journal of molecular sciences · 2023Review
- Polyketides as Secondary Metabolites from the GenusJournal of fungi (Basel, Switzerland) · 2023Review
- Peculiarities of meroterpenoids and their bioproduction.Applied microbiology and biotechnology · 2021Review
- Fungal Metabolite Asperaculane B Inhibits Malaria Infection and Transmission.Molecules (Basel, Switzerland) · 2020Article
- Natural Nitrogenous Sesquiterpenoids and Their Bioactivity: A Review.Molecules (Basel, Switzerland) · 2020Review
- Fungal endophytes from arid areas of Andalusia: high potential sources for antifungal and antitumoral agents.Scientific reports · 2018Article
- Identification of the First Diketomorpholine Biosynthetic Pathway Using FAC-MS Technology.ACS chemical biology · 2018Article
- Secondary Metabolites and Their Biological Activity from Aspergillus aculeatus KKU-CT2.Current microbiology · 2018Article
- Identification of the decumbenone biosynthetic gene cluster inFungal biology and biotechnology · 2018Article
- Does Osmotic Stress Affect Natural Product Expression in Fungi?Marine drugs · 2017Article
- Aspergillus labruscus sp. nov., a new species of Aspergillus section Nigri discovered in Brazil.Scientific reports · 2017Article
- Modern mass spectrometry for synthetic biology and structure-based discovery of natural products.Natural product reports · 2016Review
- Antifungal activity of extracts from Atacama Desert fungi against Paracoccidioides brasiliensis and identification of Aspergillus felis as a promising source of natural bioactive compounds.Memorias do Instituto Oswaldo Cruz · 2016Article
- Induced sclerotium formation exposes new bioactive metabolites from Aspergillus sclerotiicarbonarius.The Journal of antibiotics · 2015Article
- Dichlorinated and Brominated Rugulovasines, Ergot Alkaloids Produced by Talaromyces wortmannii.Molecules (Basel, Switzerland) · 2015Article
- Association of fungal secondary metabolism and sclerotial biology.Frontiers in microbiology · 2015Review
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
Investigation of the chemical profile of the industrially important black filamentous fungus Aspergillus aculeatus by UHPLC-DAD-HRMS and subsequent dereplication has led to the discovery of several novel compounds. Isolation and extensive 1D and 2D NMR spectroscopic analyses allowed for structural elucidation of a dioxomorpholine, a unique okaramine, an aflavinine and three novel structures of mixed biosynthetic origin, which we have named aculenes A-C. Moreover, known analogues of calbistrins, okaramines and secalonic acids were detected. All novel compounds were tested for antifungal activity against Candida albicans, however all showed only weak or no activity. Aspergillus aculeatus IBT 21030 was additionally shown to be capable of producing sclerotia. Examination of the sclerotia revealed a highly regulated production of metabolites in these morphological structures.
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