ArticleNeuropsychology2015
Memory for items and relationships among items embedded in realistic scenes: disproportionate relational memory impairments in amnesia.
Article in Neuropsychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Measuring relational memory in older and younger adults.Frontiers in cognition · 2025Article
- Relational memory weakness in autism despite the use of a controlled encoding task.Frontiers in psychology · 2023Article
- Temporary amnesia from sleep loss: A framework for understanding consequences of sleep deprivation.Frontiers in neuroscience · 2023Review
- Intact high-resolution working memory binding in a patient with developmental amnesia and selective hippocampal damage.Hippocampus · 2022Article
- Identifying Electroencephalography Biomarkers in Individuals at Clinical High Risk for Psychosis in an International Multi-Site Study.Frontiers in psychiatry · 2022Article
- Relational Memory in the Early Stage of Psychosis: A 2-Year Follow-up Study.Schizophrenia bulletin · 2021Article
- Translating Visual Short-Term Memory Binding Tasks to Clinical Practice: From Theory to Practice.Frontiers in neurology · 2020Article
- Enhancing memory with stress: Progress, challenges, and opportunities.Brain and cognition · 2019Review
- Exploring the neurocognitive basis of episodic recollection in autism.Psychonomic bulletin & review · 2019Review
- Comparing and Contrasting the Cognitive Effects of Hippocampal and Ventromedial Prefrontal Cortex Damage: A Review of Human Lesion Studies.Neuroscience · 2018Review
- Classic and recent advances in understanding amnesia.F1000Research · 2018Review
- Dynamic Hippocampal and Prefrontal Contributions to Memory Processes and Representations Blur the Boundaries of Traditional Cognitive Domains.Brain sciences · 2017Review
- Differential medial temporal lobe morphometric predictors of item- and relational-encoded memories in healthy individuals and in individuals with mild cognitive impairment and Alzheimer's disease.Alzheimer's & dementia (New York, N. Y.) · 2017Article
- Visual short-term memory binding deficit in familial Alzheimer's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2016Article
- Selective scanpath repetition during memory-guided visual search.Visual cognition · 2016Article
- Remembering Preservation in Hippocampal Amnesia.Annual review of psychology · 2016Review
- Hierarchical process memory: memory as an integral component of information processing.Trends in cognitive sciences · 2015Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveThe objective of this study was to examine the dependence of item memory and relational memory on medial temporal lobe (MTL) structures. Patients with amnesia, who either had extensive MTL damage or damage that was relatively restricted to the hippocampus, were tested, as was a matched comparison group. Disproportionate relational memory impairments were predicted for both patient groups, and those with extensive MTL damage were also expected to have impaired item memory.
methodParticipants studied scenes, and were tested with interleaved 2-alternative forced-choice probe trials. Probe trials were either presented immediately after the corresponding study trial (Lag 1), 5 trials later (Lag 5), or 9 trials later (Lag 9) and consisted of the studied scene along with a manipulated version of that scene in which 1 item was replaced with a different exemplar (item memory test) or was moved to a new location (relational memory test). Participants were to identify the exact match of the studied scene.
resultsAs predicted, patients were disproportionately impaired on the test of relational memory. Item memory performance was marginally poorer among patients with extensive MTL damage, but both groups were impaired relative to matched comparison participants. Impaired performance was evident at all lags, including the shortest possible lag (Lag 1).
conclusionsThe results are consistent with the proposed role of the hippocampus in relational memory binding and representation, even at short delays, and suggest that the hippocampus may also contribute to successful item memory when items are embedded in complex scenes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.