ArticleLaboratory investigation; a journal of technical methods and pathology2014
The microbiota regulates susceptibility to Fas-mediated acute hepatic injury.
Article in Laboratory investigation; a journal of technical methods and pathology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Unveiling the Molecular Repertoire ofJournal of microbiology and biotechnology · 2026Review
- Interacting roles of gut microbiota and T cells in the development of autoimmune hepatitis.Frontiers in immunology · 2025Review
- Multifunctional role of oral bacteria in the progression of non-alcoholic fatty liver disease.World journal of hepatology · 2024Review
- CSF-1R+ Macrophages Control the Gut Microbiome-Enhanced Liver Invariant NKT Function through IL-18.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Intrahepatic microbes govern liver immunity by programming NKT cells.The Journal of clinical investigation · 2022Article
- The Protective Effects of a Modified Xiaohua Funing Decoction against Acute Liver Failure in Mice Induced by D-Gal and LPS.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Gut Microbiota and Chemical-Induced Acute Liver Injury.Frontiers in physiology · 2021Review
- Temporospatial shifts within commercial laboratory mouse gut microbiota impact experimental reproducibility.BMC biology · 2020Article
- Gut microbiota in liver disease: too much is harmful, nothing at all is not helpful either.American journal of physiology. Gastrointestinal and liver physiology · 2019Review
- The links between the gut microbiome and non-alcoholic fatty liver disease (NAFLD).Cellular and molecular life sciences : CMLS · 2019Review
- Intestinal barrier regulates immune responses in the liver via IL-10-producing macrophages.JCI insight · 2018Article
- Segmented filamentous bacteria-induced immune responses: a balancing act between host protection and autoimmunity.Immunology · 2018Review
- Bifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10 attenuate D-galactosamine-induced liver injury by modifying the gut microbiota.Scientific reports · 2017Article
- Loss of Resistance to Angiotensin II-Induced Hypertension in the Jackson Laboratory Recombination-Activating Gene Null Mouse on the C57BL/6J Background.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Microbiota composition of simultaneously colonized mice housed under either a gnotobiotic isolator or individually ventilated cage regime.Scientific reports · 2017Article
- Protective Effect ofFrontiers in microbiology · 2017Article
- Antibiotic-treated versus germ-free rodents for microbiota transplantation studies.Gut microbes · 2016Article
- Clinical Presentation and Outcomes of Autoimmune Hepatitis in Inflammatory Bowel Disease.Digestive diseases and sciences · 2015Review
- Natural killer T cells play a necessary role in modulating of immune-mediated liver injury by gut microbiota.Scientific reports · 2014Article
- Approaches to discern if microbiome associations reflect causation in metabolic and immune disorders.Gut microbesReview
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
Whereas a significant role for intestinal microbiota in affecting the pathogenesis and progression of chronic hepatic diseases is well documented, the contribution of the intestinal flora to acute liver injury has not been extensively addressed. Elucidating the influence of the intestinal microbiota on acute liver inflammation would be important for better understanding the transition from acute injury to chronic liver disease. Using the Concanavalin A (ConA)-induced liver injury model in laboratory mice, we show that the severity of acute hepatic damage varies greatly among genetically identical mice raised in different environments and harboring distinct microbiota. Through reconstitution of germ-free (GF) mice, and the co-housing of conventional mice, we provide direct evidence that manipulation of the intestinal flora alters susceptibility to ConA-induced liver injury. Through deep sequencing of the fecal microbiome, we observe that the relative abundance of Ruminococcaceae, a Gram(+) family within the class Clostridia, but distinct from segmented filamentous bacteria, is positively associated with the degree of liver damage. Searching for the underlying mechanism(s) that regulate susceptibility to ConA, we provide evidence that the extent of liver injury following triggering of the death receptor Fas varies greatly as a function of the microbiota. We demonstrate that the extent of Fas-induced liver injury increases in GF mice after microbiota reconstitution, and decreases in conventionally raised mice following reduction in intestinal bacterial load, by antibiotic treatment. We also show that the regulation of sensitivity to Fas-induced liver injury is dependent upon the toll-like receptor signaling molecule MyD88. In conclusion, the status and composition of the intestinal microbiota determine the susceptibility to ConA-induced acute liver injury. The microbiota acts as a rheostat, actively modulating the extent of liver damage in response to Fas triggering.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.