Observational studyAmerican journal of ophthalmology2014
Glaucomatous retinal nerve fiber layer thickness loss is associated with slower reaction times under a divided attention task.
Observational study in American journal of ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- An examination of sustained attention during complex multitasking scenarios.Cognitive research: principles and implications · 2025Article
- The association between self-checked visual field impairment and motor vehicle accidents among Japanese taxi drivers.Scientific reports · 2025Article
- Longitudinal Simulated Driving Performance and Rates of Progressive Visual Field Loss in Glaucoma.Translational vision science & technology · 2025Article
- Impact of Glaucomatous Ganglion Cell Damage on Central Visual Function.Annual review of vision science · 2024Review
- Functional Field of View Determined by Crowding, Aging, or Glaucoma Under Divided Attention.Translational vision science & technology · 2021Article
- Glaucomatous visual fields and neurocognitive function are independently associated with poor lane maintenance during driving simulation.BMC ophthalmology · 2020Article
- Speed and accuracy of saccades in patients with glaucoma evaluated using an eye tracking perimeter.BMC ophthalmology · 2020Article
- Effects of driver compensatory behaviour on risks of critical pedestrian collisions under simulated visual field defects.PloS one · 2020Article
- Mobile Telephone Use and Reaction Time in Drivers With Glaucoma.JAMA network open · 2019Article
- Detecting Structural Progression in Glaucoma with Optical Coherence Tomography.Ophthalmology · 2017Review
- The relationship between contrast sensitivity and retinal nerve fiber layer thickness in patients with glaucoma.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2017Observational
- The correlation between cognitive performance and retinal nerve fibre layer thickness is largely explained by genetic factors.Scientific reports · 2016Article
- What rates of glaucoma progression are clinically significant?Expert review of ophthalmology · 2016Article
- Rates of Retinal Nerve Fiber Layer Loss in Contralateral Eyes of Glaucoma Patients with Unilateral Progression by Conventional Methods.Ophthalmology · 2015Observational
- How strong is the relationship between glaucoma, the retinal nerve fibre layer, and neurodegenerative diseases such as Alzheimer's disease and multiple sclerosis?Eye (London, England) · 2015Review
- Relationship Between Motor Vehicle Collisions and Results of Perimetry, Useful Field of View, and Driving Simulation in Drivers With Glaucoma.Translational vision science & technology · 2015Article
- Predicting Risk of Motor Vehicle Collisions in Patients with Glaucoma: A Longitudinal Study.PloS one · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeTo examine the relationship between glaucomatous structural damage and ability to divide attention during simulated driving.
designCross-sectional observational study.
methods
settingHamilton Glaucoma Center, University of California San Diego. PATIENT POPULATION: Total of 158 subjects from the Diagnostic Innovations in Glaucoma Study, including 82 with glaucoma and 76 similarly aged controls. OBSERVATION PROCEDURE: Ability to divide attention was investigated by measuring reaction times to peripheral stimuli (at low, medium, or high contrast) while concomitantly performing a central driving task (car following or curve negotiation). All subjects had standard automated perimetry (SAP) and optical coherence tomography was used to measure retinal nerve fiber layer (RNFL) thickness. Cognitive ability was assessed using the Montreal Cognitive Assessment and subjects completed a driving history questionnaire.
main outcome measuresReaction times to the driving simulator divided attention task.
resultsThe mean reaction times to the low-contrast stimulus were 1.05 s and 0.64 s in glaucoma and controls, respectively, during curve negotiation (P < .001), and 1.19 s and 0.77 s (P = .025), respectively, during car following. There was a nonlinear relationship between reaction times and RNFL thickness in the better eye. RNFL thickness remained significantly associated with reaction times even after adjusting for age, SAP mean deviation in the better eye, cognitive ability, and central driving task performance.
conclusionsAlthough worse SAP sensitivity was associated with worse ability to divide attention, RNFL thickness measurements provided additional information. Information from structural tests may improve our ability to determine which patients are likely to have problems performing daily activities, such as driving.
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