ReviewCritical reviews in toxicology2014
Improving the risk assessment of lipophilic persistent environmental chemicals in breast milk.
Review in Critical reviews in toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Prenatal Exposure to Organochlorine Compounds and Other Pesticides: A Systematic Review of Neonatal Health Outcomes.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2026Article
- Comparison of physiologically based pharmacokinetic modeling platforms for developmental neurotoxicity in vitro to in vivo extrapolation.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- PFC/PFAS concentrations in human milk and infant exposure through lactation: a comprehensive review of the scientific literature.Archives of toxicology · 2025Review
- Pollutants in Breast Milk: A Scoping Review of the Most Recent Data in 2024.Healthcare (Basel, Switzerland) · 2024Article
- Endocrine-Disrupting Chemicals and Their Effects in Pet Dogs and Cats: An Overview.Animals : an open access journal from MDPI · 2023Review
- A Generic Pharmacokinetic Model for Quantifying Mother-to-Offspring Transfer of Lipophilic Persistent Environmental Chemicals.Toxicological sciences : an official journal of the Society of Toxicology · 2022Article
- Identifying the link between chemical exposures and breast cancer in African American women via integrated in vitro and exposure biomarker data.Toxicology · 2021Article
- Organophosphorus Flame Retardants and Plasticizers in Breast Milk from the United States.Environmental science & technology letters · 2019Article
- New Approach Methodologies for Exposure Science.Current opinion in toxicology · 2019Article
- Environmental Chemicals in Breast Milk and Formula: Exposure and Risk Assessment Implications.Environmental health perspectives · 2018Review
- Lactational programming of glucose homeostasis: a window of opportunity.Reproduction (Cambridge, England) · 2018Review
- Incorporation of fetal and child PFOA dosimetry in the derivation of health-based toxicity values.Environment international · 2018Article
- Polybrominated Diphenyl Ethers in Human Milk and Serum from the U.S. EPA MAMA Study: Modeled Predictions of Infant Exposure and Considerations for Risk Assessment.Environmental health perspectives · 2017Article
- Endocrine Disruptors and Obesity.Current obesity reports · 2017Review
- Polychlorinated biphenyls: New evidence from the last decade.Toxicology and industrial health · 2016Article
- Concentrations of environmental phenols and parabens in milk, urine and serum of lactating North Carolina women.Reproductive toxicology (Elmsford, N.Y.) · 2015Article
- Evaluating health risks from inhaled polychlorinated biphenyls: research needs for addressing uncertainty.Environmental health perspectives · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors.
Funding
Abstract
Lipophilic persistent environmental chemicals (LPECs) have the potential to accumulate within a woman's body lipids over the course of many years prior to pregnancy, to partition into human milk, and to transfer to infants upon breastfeeding. As a result of this accumulation and partitioning, a breastfeeding infant's intake of these LPECs may be much greater than his/her mother's average daily exposure. Because the developmental period sets the stage for lifelong health, it is important to be able to accurately assess chemical exposures in early life. In many cases, current human health risk assessment methods do not account for differences between maternal and infant exposures to LPECs or for lifestage-specific effects of exposure to these chemicals. Because of their persistence and accumulation in body lipids and partitioning into breast milk, LPECs present unique challenges for each component of the human health risk assessment process, including hazard identification, dose-response assessment, and exposure assessment. Specific biological modeling approaches are available to support both dose-response and exposure assessment for lactational exposures to LPECs. Yet, lack of data limits the application of these approaches. The goal of this review is to outline the available approaches and to identify key issues that, if addressed, could improve efforts to apply these approaches to risk assessment of lactational exposure to these chemicals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.