Evidence map›Paper›PMID 25068427›Full record

Trial reportBone marrow transplantation2014

Sputum cytokine levels in patients undergoing hematopoietic SCT and comparison with healthy subjects and COPD: a pilot study.

C Moermans, C Bonnet, E Willems, F Baron, M Nguyen, M Henket, J Sele, J-L Corhay, Y Beguin, R Louis

Abstract readClinical TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Bone marrow transplantation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Sputum Cytokine Repeatability in COPD.International journal of chronic obstructive pulmonary disease · 2025
    Article
  2. Review
  3. Article
  4. Role of eosinophils in airway inflammation of chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2018
    Review
  5. Reduced sputum expression of interferon-stimulated genes in severe COPD.International journal of chronic obstructive pulmonary disease · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

C MoermansDepartment of Pneumology-Allergology, Avenue de l'hopital, CHU of Liege, I group, GIGA Research Center, University of Liege, Liege, Belgium.
C BonnetDepartment of Hematology-Oncology, CHU of Liege, I group, GIGA Research Center, University of Liege, Liege, Belgium.
E WillemsDepartment of Hematology-Oncology, CHU of Liege, I group, GIGA Research Center, University of Liege, Liege, Belgium.
F BaronDepartment of Hematology-Oncology, CHU of Liege, I group, GIGA Research Center, University of Liege, Liege, Belgium.
M NguyenDepartment of Pneumology-Allergology, Avenue de l'hopital, CHU of Liege, I group, GIGA Research Center, University of Liege, Liege, Belgium.
M HenketDepartment of Pneumology-Allergology, Avenue de l'hopital, CHU of Liege, I group, GIGA Research Center, University of Liege, Liege, Belgium.
J SeleDepartment of Pneumology-Allergology, Avenue de l'hopital, CHU of Liege, I group, GIGA Research Center, University of Liege, Liege, Belgium.
J-L CorhayDepartment of Pneumology-Allergology, Avenue de l'hopital, CHU of Liege, I group, GIGA Research Center, University of Liege, Liege, Belgium.
Y BeguinDepartment of Hematology-Oncology, CHU of Liege, I group, GIGA Research Center, University of Liege, Liege, Belgium.
R LouisDepartment of Pneumology-Allergology, Avenue de l'hopital, CHU of Liege, I group, GIGA Research Center, University of Liege, Liege, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients undergoing hematopoietic SCT (HSCT) display an airway neutrophilic inflammation before transplantation that persists over the years. In this study, we have investigated the cytokine profile over a period of 1 year in the sputum supernatant of patients who underwent HSCT. We have measured sputum supernatant levels of TNF-α, TGF-β1, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, IL-17 and IFN-γ in 49 HSCT patients and compared the results with those found in 40 chronic obstructive pulmonary disease (COPD) and 54 healthy subjects matched for age. Compared with healthy subjects, before transplantation, HSCT patients exhibited raised levels of IL-6 (P<0.001) and IL-8 (P<0.05) while the other cytokines were generally poorly detectable. This picture was rather similar to that seen in COPD even if cytokine levels were much greater in the latter, with IL-8 being significantly greater in COPD than in HSCT patients (P<0.0001). In the 1 year following transplantation, sputum IL-6 and IL-8 did not differ from those in healthy subjects. Overall in HSCT patients, sputum IL-8 and IL-6 correlated with sputum neutrophil counts (r=0.4, P<0.0001; r=0.42, P<0.0001, respectively). In conclusion, sputum IL-6 and IL-8 may play a role in neutrophilic airway inflammation seen in patients undergoing HSCT.

Indexed as

AdultAgedAllograftsCytokinesFemaleFollow-Up StudiesHematopoietic Stem Cell TransplantationHumansMaleMiddle AgedNeutrophilsPilot ProjectsPulmonary Disease, Chronic ObstructiveSputumCytokines

Identifiers

PMID25068427

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.