ArticleStem cell reports2014
Modulating innate immunity improves hepatitis C virus infection and replication in stem cell-derived hepatocytes.
Article in Stem cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- The Intrinsic Innate Immunity of Hepatocytes Suppresses HBV Replication and Is Antagonized by HBx.Viruses · 2025Article
- Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes.Stem cell reports · 2022Article
- Review
- Efficient acute and chronic infection of stem cell-derived hepatocytes by hepatitis C virus.Gut · 2020Article
- Human PSC-Derived Hepatocytes Express Low Levels of Viral Pathogen Recognition Receptors, but Are Capable of Mounting an Effective Innate Immune Response.International journal of molecular sciences · 2020Article
- Review
- Stem Cell-Derived Hepatocyte-Like Cells as Model for Viral Hepatitis Research.Stem cells international · 2019Review
- Innate immunity in stem cell-derived hepatocytes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Modelling non-alcoholic fatty liver disease in human hepatocyte-like cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Designer human tissue: coming to a lab near you.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Functional innate immunity restricts Hepatitis C Virus infection in induced pluripotent stem cell-derived hepatocytes.Scientific reports · 2018Article
- Article
- Article
- Lipidomic profiling of patient-specific iPSC-derived hepatocyte-like cells.Disease models & mechanisms · 2017Article
- Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses.Nature communications · 2017Article
- Defined and Scalable Generation of Hepatocyte-like Cells from Human Pluripotent Stem Cells.Journal of visualized experiments : JoVE · 2017Article
- Prediction of Differentiation Tendency Toward Hepatocytes from Gene Expression in Undifferentiated Human Pluripotent Stem Cells.Stem cells and development · 2016Article
- Pluripotent Stem Cell-Derived Hepatocyte-like Cells: A Tool to Study Infectious Disease.Current pathobiology reports · 2016Article
- Anti-hepatitis C virus potency of a new autophagy inhibitor using human liver slices model.World journal of hepatology · 2016Article
- Exploration of acetanilide derivatives of 1-(ω-phenoxyalkyl)uracils as novel inhibitors of Hepatitis C Virus replication.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
In this study, human embryonic stem cell-derived hepatocytes (hESC-Heps) were investigated for their ability to support hepatitis C virus (HCV) infection and replication. hESC-Heps were capable of supporting the full viral life cycle, including the release of infectious virions. Although supportive, hESC-Hep viral infection levels were not as great as those observed in Huh7 cells. We reasoned that innate immune responses in hESC-Heps may lead to the low level of infection and replication. Upon further investigation, we identified a strong type III interferon response in hESC-Heps that was triggered by HCV. Interestingly, specific inhibition of the JAK/STAT signaling pathway led to an increase in HCV infection and replication in hESC-Heps. Of note, the interferon response was not evident in Huh7 cells. In summary, we have established a robust cell-based system that allows the in-depth study of virus-host interactions in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.